Professor Steve Winder

School of Biosciences

Emeritus Professor

Director of Recruitment and International Relations

s.winder@sheffield.ac.uk

Full contact details

Professor Steve Winder
School of Biosciences
B206
Firth Court
Western Bank
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S10 2TN
Profile

Brief career history

  • 2005-Present: Professor of Molecular Cell Biology, School of Biosciences, University of ߲ݴý
  • 2003-2005: Reader, Department of Biomedical Science, University of ߲ݴý
  • 1999-2003: Lecturer (99-01) Reader (02-03), University of Glasgow
  • 1995-1999: Wellcome Trust Fellow, ICMB, University of Edinburgh
  • 1992-1995: Staff Scientist, Laboratory of Molecular Biology, Cambridge - Advisor, Jake Kendrick-Jones
  • 1988-1992: Postdoctoral Fellow, Biochemistry, University of Calgary, Advisor - Mike Walsh.
  • 1984-1988: PhD, University of Reading, Supervisor - Isabel Forsyth
Research interests

Regulation of dystroglycan function in muscular dystrophy and cancer

The laminin binding protein dystroglycan plays multiple roles in cell adhesion, signalling and membrane cytoskeleton stability. Perturbation of dystroglycan function underlies several muscular dystrophies and is also a secondary consequence of adenocarcinoma progression.

Changes to the post-translational modification of dystroglycan are crucial in directing the associations, cellular localisation and ultimately degradation of dystroglycan.

Our aim is to elucidate the mechanisms and consequences of these post-translational modifications in order to better understand dystroglycan function and to identify potential therapeutic targets for the treatment of muscular dystrophy or cancer.

We employ in vitro, in/ex vivo fish and mouse genetic models with clinically relevant archival tissue samples or immortalised cell lines. Dystroglycan function is dissected through the use of molecular cell biology approaches, and potential therapeutic targets are assessed in vitro and in vivo.

Recently we have developed a novel therapeutic approach for the treatment of Duchenne muscular dystrophy using inhibitors of tyrosine phosphorylation and proteasomal degradation. Through the use of zebrafish screening and phenotypic analysis in mdx mice and human DMD myoblasts we are in the process of validating the potential for repurposed drugs as a precursor to initiating clinical trials.

Physiological analysis is carried out I collaboration with Nic Wells at the RVC London.

In vitro models of prostate cancer have revealed a role for the post-translational proteolytic processing and nuclear targeting of dystroglycan.

Current efforts are centred around characterising a role as part of the LINC complex in the inner nuclear membrane. These studies form part of an ongoing collaboration with Bulmaro Cisneros, CINVESTAV Mexico City.

Funding

  • Action Duchenne - Repurposed Cancer Therapeutics as Treatments for DMD
  • Duchenne UK - Are soy products effective in DMD?
  • White Rose - The Dystroglycan LINC
  • Action on Hearing Loss - Dystroglycan function in hearing and hearing loss
Publications

Show: Featured publications All publications

Journal articles

  • Lipscomb L, Piggott RW, Emmerson T & Winder SJ (2016) . Human Molecular Genetics, 25(2), 266-274. RIS download Bibtex download
  • Martínez-Vieyra IA, Vásquez-Limeta A, González-Ramírez R, Morales-Lázaro SL, Mondragón M, Mondragón R, Ortega A, Winder SJ & Cisneros B (2013) . Biochimica et Biophysica Acta - Molecular Cell Research, 1833(3), 698-711. RIS download Bibtex download
  • Mathew G, Mitchell A, Down JM, Jacobs LA, Hamdy FC, Eaton C, Rosario DJ, Cross SS & Winder SJ (2013) . Sci Rep, 3, 2792. RIS download Bibtex download
  • Miller G, Moore CJ, Terry R, La riviere T, Mitchell A, Piggott R, Dear TN, Wells DJ & Winder SJ (2012) . Human Molecular Genetics, 21(20), 4508-4520. RIS download Bibtex download
  • García‐Aguirre I, Alamillo‐Iniesta A, Rodríguez‐Pérez R, Vélez‐Aguilera G, Amaro‐Encarnación E, Jiménez‐Gutiérrez E, Vásquez‐Limeta A, Samuel Laredo‐Cisneros M, Morales‐Lázaro SL, Tiburcio‐Félix R , Ortega A et al () . Aging Cell. RIS download Bibtex download

All publications

Journal articles

  • Gómez-Monsivais WL, Monterrubio-Ledezma F, Huerta-Cantillo J, Mondragon-Gonzalez R, Alamillo-Iniesta A, García-Aguirre I, Azuara-Medina PM, Arguello-García R, Rivera-Monroy JE, Holaska JM , Hernández-Méndez JME et al (2020) . International Journal of Molecular Sciences, 21(17). RIS download Bibtex download
  • Mias-Lucquin D, Dos Santos Morais R, Chéron A, Lagarrigue M, Winder SJ, Chenuel T, Pérez J, Appavou M-S, Martel A, Alviset G , Le Rumeur E et al (2020) . Journal of Structural Biology, 209(1). RIS download Bibtex download
  • Azuara-Medina P, Sandoval-Duarte A, Morales-Lázaro S, Modragón-González R, Vélez-Aguilera G, Gómez-López J, Jiménez-Gutiérrez G, Tiburcio-Félix R, Martínez-Vieyra I, Sánchez R , Längst G et al (2019) . Cell Death and Disease, 10. RIS download Bibtex download
  • Gracida-Jiménez V, Mondragón-González R, Vélez-Aguilera G, Vásquez-Limeta A, Laredo-Cisneros MS, de Dios Gómez-López J, Vaca L, Gourlay SC, Jacobs LA, Winder SJ & Cisneros B (2018) . Scientific Reports, 8. RIS download Bibtex download
  • Vélez-Aguilera G, de Dios Gómez-López J, Jiménez-Gutiérrez GE, Vásquez-Limeta A, Laredo-Cisneros MS, Gómez P, Winder SJ & Cisneros B (2018) . Biochimica et Biophysica Acta - Molecular Cell Research, 1865(2), 406-420. RIS download Bibtex download
  • Gracida-Jiménez V, Mondragón-González R, Vélez-Aguilera G, Vásquez-Limeta A, Laredo-Cisneros MS, Gómez-López JDD, Vaca L, Gourlay SC, Jacobs LA, Winder SJ & Cisneros B (2017) . Scientific Reports, 7(1). RIS download Bibtex download
  • Alonso-Rangel L, Benítez-Guerrero T, Martínez-Vieyra I, Cisneros B, Martínez-Tovar A, Winder SJ & Cerecedo D (2017) . Life Sciences, 182, 1-9. RIS download Bibtex download
  • Brown SC & Winder SJ (2017) . Neuromuscular Disorders, 27(4). RIS download Bibtex download
  • Leocadio D, Mitchell A & Winder SJ (2016) . Journal of Cellular Biochemistry, 117(9), 2149-2157. RIS download Bibtex download
  • Hoffman E & Winder SJ (2016) . PLoS Currents. RIS download Bibtex download
  • Lipscomb L, Piggott RW, Emmerson T & Winder SJ (2016) . Human Molecular Genetics, 25(2), 266-274. RIS download Bibtex download
  • Escárcega-Tame MA, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2015) . PLOS ONE, 10(12), e0144078-e0144078. RIS download Bibtex download
  • Tetlow DJ, Winder SJ & Aïssa C (2015) . Chem. Commun., 52(4), 807-810. RIS download Bibtex download
  • Leiton CV, Aranmolate A, Eyermann C, Menezes MJ, Escobar-Hoyos LF, Husain S, Winder SJ & Colognato H (2015) . Journal of Neurochemistry, 135(3), 522-538. RIS download Bibtex download
  • Cerecedo D, Martínez-Vieyra I, Maldonado-García D, Hernández-González E & Winder SJ (2015) . Journal of Cellular Biochemistry, 116(11), 2528-2540. RIS download Bibtex download
  • Tame ME, Martinez-Vieyra I, Cisneros B, Winder SJ & Cerecedo D (2014) Dystroglycan depletion inhibits the functions of differentiated Kasumi-1 cells.. MOLECULAR BIOLOGY OF THE CELL, 25. RIS download Bibtex download
  • Martínez-Zárate AD, Martínez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2014) . Biochem Biophys Res Commun, 448(3), 274-280. RIS download Bibtex download
  • Singh SM, Bandi S, Winder SJ & Mallela KMG (2014) . Biochemistry, 53(11), 1801-1809. RIS download Bibtex download
  • Martínez-Vieyra IA, Vásquez-Limeta A, González-Ramírez R, Morales-Lázaro SL, Mondragón M, Mondragón R, Ortega A, Winder SJ & Cisneros B (2013) . Biochimica et Biophysica Acta - Molecular Cell Research, 1833(3), 698-711. RIS download Bibtex download
  • Mathew G, Mitchell A, Down JM, Jacobs LA, Hamdy FC, Eaton C, Rosario DJ, Cross SS & Winder SJ (2013) . Sci Rep, 3, 2792. RIS download Bibtex download
  • Sarkis J, Víe V, Winder SJ, Renault A, Le Rumeur E & Hubert JF (2013) . FASEB Journal, 27(1), 359-367. RIS download Bibtex download
  • Mitchell A, Mathew G, Jiang T, Hamdy FC, Cross SS, Eaton C & Winder SJ (2013) . Prostate, 73(4), 398-408. RIS download Bibtex download
  • Moore CJ & Winder SJ (2012) . Neuromuscul Disord, 22(11), 959-965. RIS download Bibtex download
  • Thompson O, Moghraby JS, Ayscough KR & Winder SJ (2012) . BMC Cell Biol, 13, 1. RIS download Bibtex download
  • Miller G, Moore CJ, Terry R, La riviere T, Mitchell A, Piggott R, Dear TN, Wells DJ & Winder SJ (2012) . Human Molecular Genetics, 21(20), 4508-4520. RIS download Bibtex download
  • Brown SC & Winder SJ (2012) . Neuromuscular Disorders, 22(7), 659-668. RIS download Bibtex download
  • Le Rumeur E, Hubert JF & Winder SJ (2012) . FEBS Letters, 586(17), 2717-2722. RIS download Bibtex download
  • Le Rumeur E, Hubert J-F & Winder SJ (2012) A new twist to coiled coil. FEBS Letters. RIS download Bibtex download
  • Broderick MJF, Bobkov A & Winder SJ (2012) . FEBS Open Bio, 2, 6-11. RIS download Bibtex download
  • Singh SM, Molas JF, Kongari N, Bandi S, Mallela KMG, Armstrong GS & Winder SJ (2012) . Proteins: Structure, Function and Bioformatics. RIS download Bibtex download
  • Brown SC & Winder SJ (2012) Dystroglycan and dystroglycanopathies: Report of the 187th ENMC Workshop 11-13 November 2011, Naarden, The Netherlands. Neuromuscular Disorders. RIS download Bibtex download
  • Parberry-Clark C, Bury JP, Cross SS & Winder SJ (2011) . Histopathology, 59(2), 180-187. RIS download Bibtex download
  • Winder SJ, Lipscomb L, Angela Parkin C & Juusola M (2011) . PLoS Curr, 3, RRN1286. RIS download Bibtex download
  • Le Rumeur E, Winder SJ & Hubert JF (2010) . BBA-PROTEINS PROTEOM, 1804(9), 1713-1722. RIS download Bibtex download
  • Moore CJ & Winder SJ (2010) . Cell Commun Signal, 8, 3. RIS download Bibtex download
  • Thompson O, Moore CJ, Hussain S-A, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K & Winder SJ (2010) . J Cell Sci, 123(Pt 1), 118-127. RIS download Bibtex download
  • Robertson AS, Allwood EG, Smith APC, Gardiner FC, Costa R, Winder SJ & Ayscough KR (2009) . Mol Biol Cell, 20(6), 1618-1628. RIS download Bibtex download
  • Cross SS, Lippitt J, Mitchell A, Hollingsbury F, Balasubramanian SP, Reed MWR, Eaton C, Catto JW, Hamdy F & Winder SJ (2008) . Histopathology, 53(5), 561-566. RIS download Bibtex download
  • Gheorghe DM, Aghamohammadzadeh S, Smaczynska-de Rooij II, Allwood EG, Winder SJ & Ayscough KR (2008) . J Biol Chem, 283(22), 15037-15046. RIS download Bibtex download
  • Bryant RJ, Winder SJ, Cross SS, Hamdy FC & Cunliffe VT (2008) . Prostate, 68(3), 255-263. RIS download Bibtex download
  • Thompson O, Kleino I, Crimaldi L, Gimona M, Saksela K & Winder SJ (2008) . PLoS One, 3(11), e3638. RIS download Bibtex download
  • Higginson JR, Thompson O & Winder SJ (2008) . Int J Biochem Cell Biol, 40(5), 892-900. RIS download Bibtex download
  • Avizienyte E, Keppler M, Sandilands E, Brunton VG, Winder SJ, Ng T & Frame MC (2007) . EXP CELL RES, 313(15), 3175-3188. RIS download Bibtex download
  • Anderson C, Winder SJ & Borycki A-G (2007) . Dev Dyn, 236(9), 2627-2635. RIS download Bibtex download
  • Rezniczek GA, Konieczny P, Nikolic B, Reipert S, Schneller D, Abrahamsberg C, Davies KE, Winder SJ & Wiche G (2007) Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan. J CELL BIOL, 176(7), 965-977. RIS download Bibtex download
  • Hnia K, Zouiten D, Cantel S, Chazalette D, Hugon G, Fehrentz JA, Masmoudi A, Diment A, Bramham J, Mornet D & Winder SJ (2007) . BIOCHEM J, 401, 667-677. RIS download Bibtex download
  • Batchelor CL, Higginson JR, Chen Y-J, Vanni C, Eva A & Winder SJ (2007) . Cell Cycle, 6(3), 353-363. RIS download Bibtex download
  • Lin N, Chen A, Mackley JR, Winder SJ & Yokota H (2007) . AIP Conference Proceedings, 953, 122-131. RIS download Bibtex download
  • Mackley JR, Ando J, Herzyk P & Winder SJ (2006) . Biochem J, 396(2), 307-316. RIS download Bibtex download
  • Batchelor CL & Winder SJ (2006) . Trends Cell Biol, 16(4), 198-205. RIS download Bibtex download
  • Thompson O, Winder S & Peckham M (2006) . The FASEB Journal, 20(5), lb3-lb3. RIS download Bibtex download
  • Higginson JR & Winder SJ (2005) . Biochem Soc Trans, 33(Pt 6), 1254-1255. RIS download Bibtex download
  • Winder SJ & Ayscough KR (2005) . J Cell Sci, 118(Pt 4), 651-654. RIS download Bibtex download
  • Broderick MJF & Winder SJ (2005) . Adv Protein Chem, 70, 203-246. RIS download Bibtex download
  • Winder SJ (2004) . Biochem J, 384(Pt 1), e1-e2. RIS download Bibtex download
  • Ayscough KR & Winder SJ (2004) . EMBO Rep, 5(10), 947-952. RIS download Bibtex download
  • Spence HJ, Chen YJ, Batchelor CL, Higginson JR, Suila H, Carpen O & Winder SJ (2004) . HUM MOL GENET, 13(15), 1657-1668. RIS download Bibtex download
  • Spence HJ, Dhillon AS, James M & Winder SJ (2004) . EMBO REP, 5(5), 484-489. RIS download Bibtex download
  • Gourlay CW, Carpp LN, Timpson P, Winder SJ & Ayscough KR (2004) . J Cell Biol, 164(6), 803-809. RIS download Bibtex download
  • Chen YJ, Spence HJ, Cameron JM, Jess T, Ilsley JL & Winder SJ (2003) Direct interaction of beta-dystroglycan with F-actin. BIOCHEM J, 375, 329-337. RIS download Bibtex download
  • Winder SJ, Jess T & Ayscough KR (2003) . Biochem J, 375(Pt 2), 287-295. RIS download Bibtex download
  • Winder SJ & Marston G () . PLoS Currents. RIS download Bibtex download
  • García‐Aguirre I, Alamillo‐Iniesta A, Rodríguez‐Pérez R, Vélez‐Aguilera G, Amaro‐Encarnación E, Jiménez‐Gutiérrez E, Vásquez‐Limeta A, Samuel Laredo‐Cisneros M, Morales‐Lázaro SL, Tiburcio‐Félix R , Ortega A et al () . Aging Cell. RIS download Bibtex download

Chapters

  • Gimona M & Winder SJ () Wiley-VCH Verlag GmbH & Co. KGaA RIS download Bibtex download
  • Gimona M & Winder SJ () , Modular Protein Domains (pp. 321-336). Wiley-VCH Verlag GmbH & Co. KGaA RIS download Bibtex download

Conference proceedings papers

  • Aguilera GV, Lopez JG, Gutierrez EJ, Limeta AV, Cisneros ML, Winder SJ & Cisneros-Vega B (2016) CRM1 mediates nuclear export of beta dystroglycan to maintain correct nuclear envelope integrity and function.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27 RIS download Bibtex download
  • Cerecedo DA, Martinez-Vieyra I, Maldonado DG, Hernandez EG & Winder SJ (2015) Association of membrane/lipid rafts with the platelet cytoskeleton and the Caveolin PY14 and its Participation in the Adhesion Process. MOLECULAR BIOLOGY OF THE CELL, Vol. 26 RIS download Bibtex download
  • Martinez-Zarate A, Martinez-Vieyra I, Alonso-Rangel L, Cisneros B, Winder SJ & Cerecedo D (2014) Dystroglycan depletion inhibits the functions of differentiated HL-60 cells.. MOLECULAR BIOLOGY OF THE CELL, Vol. 25 RIS download Bibtex download
  • Moore C, Mitchell A, La Riviere T, Lipscombe L, Piggott R, Parkin C, Miller G & Winder SJ (2011) . NEUROMUSCULAR DISORDERS, Vol. 21(9-10) (pp 639-639) RIS download Bibtex download
  • Miller G, Moore C, Lipscomb L, Mitchell A & Winder S (2010) . Neuromuscular Disorders, Vol. 20 (pp S13-S13) RIS download Bibtex download
  • Cross SS, Hollingbury FE, Lippitt JM, Evans CA, Balasubramanian SP, Reed MWR, Handy FC & Winder SJ (2005) Loss of intercellular expression of beta-dystroglycan is a common event in breast cancer. JOURNAL OF PATHOLOGY, Vol. 205 (pp 8-8) RIS download Bibtex download
  • Cross SS, Hollingbury FE, Lippitt JM, Feeley KM, Azzouzi AR, Winder SJ & Hamdy FC (2005) Loss of intercellular expression of beta-dystroglycan is a common event in prostate cancer and is significantly associated with loss of differentiation. JOURNAL OF PATHOLOGY, Vol. 205 (pp 15-15) RIS download Bibtex download
  • Cross SS, Hollingbury FE, Lippitt JM, Catto JW, Hamdy EC & Winder SJ (2005) beta-dystroglycan is constitutively expressed at the intercellular junctions of epithelial cells and this expression is frequently absent in common cancers. JOURNAL OF PATHOLOGY, Vol. 205 (pp 6-6) RIS download Bibtex download
  • Batchelor CL & Winder SJ (2004) ERM-dependent regulation of the actin cytoskeleton by beta-dystroglycan. MOLECULAR BIOLOGY OF THE CELL, Vol. 15 (pp 171A-171A) RIS download Bibtex download

Datasets

  • Winder S . RIS download Bibtex download
Teaching activities

Level 1

  • BMS109 Cell Biology
  • BMS110 Research Topics in Biomedicine

Level 3

  • Practical and Dissertation Modules

Level 4/Masters (MSc)

  • BMS402 Laboratory Research Project (MBiomedSci)
  • BMS6052 Laboratory Research Project (MSc)
Professional activities and memberships
  • Member of the Scientific Advisory Board for Duchenne UK
  • Member of the TREAT NMD Advisory Committee on Therapeutics (TACT)
  • Member of Editorial Boards of: International Journal of Cell Biology, BioMed Research International, PLoS Currents Muscular Dystrophy, Investigación en Discapacidad, Protein Modules Consortium.
  • External examiner for Molecular Medicine BSc, School of Biological Sciences, University of Edinburgh, Quinquennial review of MSc in Molecular Medicine, School of Biological Sciences, UEA, External Advisory Board for Biomedical Science, International Islamic University Malaysia, External Advisor to the Board of Studies for Biochemistry, Ramnarain Ruia College, Mumbai,
  • Recent Invited Conference presentations: 220th ENMC Workshop on ‘Dystroglycan and the dystroglycanopathies’, Naarden, Holland. EMBO Workshop on ‘The modularity of signalling proteins and networks’, Seefeld, Austria. IIUM Zebrafish Workshop, Kuantan, Malaysia. Action Duchenne International Conference, London. 5th International Workshop for Glycosylation Defects in Muscular Dystrophies, Charlotte, NC, USA.
  • Member of British Society for Cell Biology and Biochemical Society