Cunliffe, Vincent, Dr

Dr Vincent Cunliffe

School of Biosciences

Senior Lecturer in Developmental Genetics

v.t.cunliffe@sheffield.ac.uk
+44 114 222 2389

D18d, Firth Court

Full contact details

Dr Vincent Cunliffe
School of Biosciences
D18d
Firth Court
Western Bank
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S10 2TN

Profile

2007 - present: Senior Lecturer
2002 - 2007: Lecturer
1997 - 2002: Lister Institute Research Fellow, Department of Biomedical Science, University of ��߲ݴ�ý
1994 - 1997: Group Leader in Molecular and Cell Biology, Therexsys Ltd, Keele, UK
1991 - 1994: Postdoctoral Fellow, Division of Developmental Biology, National Institute for Medical Research, London, UK
1990: Postdoctoral Fellow, Postdoctoral Fellow, Department of Biochemistry, University of Washington, Seattle, USA
1986 - 1990: PhD, Imperial Cancer Research Fund and University College, London
1982 - 1986: BSc, University of Edinburgh

Research interests

Our research is focused primarily on understanding the roles of epigenetic mechanisms in the development and function of the zebrafish Central Nervous System (CNS), and how gene-environment interactions impact on these processes. In addition, we are exploiting the practical advantages of the zebrafish as a model organism to investigate the functions of genes implicated in human neurological disorders and cancer.

Integration of synaptic and neuroendocrine signalling and the role of the neural epigenome in health and disease

Epigenetic mechanisms regulate gene expression in response to a wide range of intercellular signals, conferring robustness to developmental processes and ensuring that there is a broad and reliable correspondence between genotype and phenotype. However, it is becoming apparent that epigenetic mechanisms also provide an experience-sensitive interface through which phenotypic plasticity is regulated in response to a wide range of environmental and behavioural signals across the lifecourse, and that these interactions can cause phenotypic changes that may be adaptive or maladaptive.

We aim to understand the roles of the epigenetic machinery, both in conferring developmental robustness and in mediating experience-sensitive phenotypic plasticity, within the zebrafish CNS. A particular focus is on understanding how experience-sensitive changes in synaptic activity and/or neuroendocrine signalling are integrated at the epigenomic level, and how the resulting changes in gene expression affect brain function.

We are collaborating with Dr Nils Krone to elucidate the impacts of altered steroid hormone signaling on zebrafish brain development and function, using novel mutants in which glucocorticoid synthesis and/or signalling is defective. We are also developing zebrafish models of nervous system disorders, such as epilepsy, by generating mutations in zebrafish orthologues of human epilepsy genes that are involved in synaptic vesicle formation and function. These models may be useful subjects of in vivo chemical screens to identify novel therapeutics for epilepsy and other disorders.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Eachus H, Zaucker A, Oakes JA, Griffin A, Weger M, Güran T, Taylor A, Harris A, Greenfield A, Quanson JL , Storbeck K-H et al (2017) . Endocrinology, 158(12), 4165-4173.
Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD & Watt PJ (2017) . Human Molecular Genetics, 26(11), 1992-2005.
Vineis P, Chatziioannou A, Cunliffe VT, Flanagan JM, Hanson M, Kirsch-Volders M & Kyrtopoulos S (2017) . FASEB J.
Cunliffe VT (2016) . Epigenomics, 8(12), 1653-1669.
Cunliffe VT (2016) . Methods in Cell Biology, 135, 361-385.
Cunliffe VT (2016) . Journal of Neuroscience Methods, 260, 91-95.
Cunliffe VT (2015) . Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.
Jackson HE, Ono Y, Wang X, Elworthy S, Cunliffe VT & Ingham PW (2015) . Skeletal Muscle, 5(1), 2-2.
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M , Hajji N et al (2015) . Nature Communications, 6.
Cunliffe VT, Baines RA, Giachello CNG, Lin W-H, Morgan A, Reuber M, Russell C, Walker MC & Williams RSB (2015) . Seizure, 24, 44-51.

All publications

Journal articles

Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) . Dis Model Mech.
Bacila I, Cunliffe VT & Krone NP (2021) . Molecular and Cellular Endocrinology, 535, 111372-111372.
Jones A, Barker‐Haliski M, Ilie AS, Herd MB, Baxendale S, Holdsworth CJ, Ashton J, Placzek M, Jayasekera BAP, Cowie CJA , Lambert JJ et al (2020) . Epilepsia.
Oakes JA, Barnard L, Storbeck K-H, Cunliffe VT & Krone NP (2020) . Journal of Endocrinology.
Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone N (2020) . Journal of Endocrinology, 244(2), 309-321.
Oakes JA, Li N, Wistow BRC, Griffin A, Barnard L, Storbeck K-H, Cunliffe VT & Krone NP (2019) . Endocrinology.
Wu X, Scott H, Carlsson SV, Sjoberg DD, Cerundolo L, Lilja H, Prevo R, Rieunier G, Macaulay V, Higgins GS , Verrill CL et al (2019) . The Prostate, 79(10), 1079-1089.
Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018) . Journal of Cerebral Blood Flow and Metabolism.
Wong SQ, Jones A, Dodd S, Grimes D, Barclay JW, Marson AG, Cunliffe VT, Burgoyne RD, Sills GJ & Morgan A (2018) . Journal of Neuroscience Methods, 309, 132-142.
Bergmann K, Meza Santoscoy P, Lygdas K, Nikolaeva Y, MacDonald R, Cunliffe V & Nikolaev AV (2018) . Journal of Developmental Biology, 6(1).
Lehane D, Cunliffe V, Mitchell C & Burton C (2018) . British Journal of General Practice, 68(666), 8-9.
Eachus H, Zaucker A, Oakes JA, Griffin A, Weger M, Güran T, Taylor A, Harris A, Greenfield A, Quanson JL , Storbeck K-H et al (2017) . Endocrinology, 158(12), 4165-4173.
Cunliffe VT & Eachus (2017) . Translational Epigenetics, 4, 251-270.
Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) . Matrix Biology, 62, 58-74.
Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD & Watt PJ (2017) . Human Molecular Genetics, 26(11), 1992-2005.
Vineis P, Chatziioannou A, Cunliffe VT, Flanagan JM, Hanson M, Kirsch-Volders M & Kyrtopoulos S (2017) . FASEB J.
Cunliffe VT (2016) . Epigenomics, 8(12), 1653-1669.
Cunliffe VT (2016) . Methods in Cell Biology, 135, 361-385.
Cunliffe VT (2016) . Journal of Neuroscience Methods, 260, 91-95.
Boyd PJ, Cunliffe VT, Roy S & Wood JD (2015) . Biology Open, 4(10), 1336-1343.
Cunliffe VT (2015) . Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.
Jackson HE, Ono Y, Wang X, Elworthy S, Cunliffe VT & Ingham PW (2015) . Skeletal Muscle, 5(1), 2-2.
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M , Hajji N et al (2015) . Nature Communications, 6.
Cunliffe VT, Baines RA, Giachello CNG, Lin W-H, Morgan A, Reuber M, Russell C, Walker MC & Williams RSB (2015) . Seizure, 24, 44-51.
Baxendale S, Holdsworth CJ, Meza Santoscoy PL, Harrison MRM, Fox J, Parkin CA, Ingham PW & Cunliffe VT (2012) . Dis Model Mech, 5(6), 773-784.
Harrison MRM, Georgiou AS, Spaink HP & Cunliffe VT (2011) . BMC Genomics, 12, 24.
Lightman EG, Harrison MRM & Cunliffe VT (2011) . Int J Dev Biol, 55(6), 597-602.
Butler R, Wood JD, Landers JA & Cunliffe VT (2010) . Dis Model Mech, 3(11-12), 743-751.
Walker RA, Cunliffe VT, Whittle JD, Steele DA & Short RD (2009) . Langmuir, 25(8), 4243-4246.
Wood JD, Bonath F, Kumar S, Ross CA & Cunliffe VT (2009) . Hum Mol Genet, 18(3), 391-404.
Prajsnar TK, Cunliffe VT, Foster SJ & Renshaw SA (2008) . Cell Microbiol, 10(11), 2312-2325.
Cunliffe VT (2008) . Curr Opin Genet Dev, 18(5), 404-410.
Bryant RJ, Winder SJ, Cross SS, Hamdy FC & Cunliffe VT (2008) . Prostate, 68(3), 255-263.
Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007) . Prostate, 67(5), 547-556.
Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007) The polycomb group protein EZH2 is required for transcriptional repression of p21 and MMP7 in prostate cancer cells. EUR UROL SUPPL, 6(2), 131-131.
Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ & Cunliffe VT (2006) . Hum Mol Genet, 15(18), 2763-2771.
Cunliffe VT & Casaccia-Bonnefil P (2006) . Mech Dev, 123(1), 24-30.
Johns SA, Soullier S, Rashbass P & Cunliffe VT (2005) . Dev Dyn, 232(4), 1062-1068.
Cunliffe VT (2004) . Development, 131(12), 2983-2995.
CUNLIFFE VT (2003) . Genetical Research, 82(1), 79-79.
Cunliffe VT (2003) . Gene, 305(2), 141-150.
Showell C & Cunliffe VT (2002) . Gene, 291(1-2), 95-104.
Cunliffe VT, Furley AJW & Keenan D (2002) . Mamm Genome, 13(5), 245-252.
Showell C, Rafferty JB & Cunliffe VT (2001) Functional studies of the Xenopus Polycomb-group proteins Xeed and XEz.. DEV BIOL, 235(1), 262-263.
Cunliffe V (2000) . Trends in Genetics, 16(3), 116-116.
Cunliffe V (1999) . Trends in Genetics, 15(8), 306-306.
Cunliffe VT & Ingham PW (1999) . Genes Dev, 13(13), 1643-1646.
Fraisier C, Abraham DA, van Oijen M, Cunliffe V, Irvine A, Craig R & Dzierzak EA (1998) . Gene Therapy, 5(7), 946-954.
Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1998) Erratum: The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (Genes and Development (1997) 11 (3265-3276)). Genes and Development, 12(8), 1240.
Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1998) The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (vol 11, pg 3265, 1997). GENES & DEVELOPMENT, 12(8), 1240-1240.
Latinkic BV, Umbhauer M, Neal KA, Smith JC & Cunliffe V (1997) Regulation of the frog brachyury promoter by activin and FGF. FASEB Journal, 11(9).
Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1997) . Genes & Development, 11(23), 3265-3276.
Cunliffe V, Thatcher D & Craig R (1995) . Current Opinion in Biotechnology, 6(6), 709-713.
O'Reilly MAJ, Smith JC & Cunliffe V (1995) Patterning of the mesoderm in Xenopus: Dose-dependent and synergistic effects of Brachyury and Pintallavis. Development, 121(5), 1351-1359.
Smith JC, Cunliffe V, O'Reilly M-AJ, Schulte-Merker S & Umbhauer M (1995) . Seminars in Developmental Biology, 6(6), 405-410.
Cunliffe V & Smith JC (1994) . The EMBO Journal, 13(2), 349-359.
(1993) . Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 340(1293), 287-296.
Cunliffe V & Smith JC (1992) . Nature, 358(6385), 427-430.
Cunliffe V, Koopman P, McLaren A & Trowsdale J (1990) . The EMBO Journal, 9(1), 197-205.
Cunliffe V, Williams S & Trowsdale J (1990) . Genomics, 8(2), 331-339.
Cunliffe V & Trowsdale J (1987) . Journal of Medical Genetics, 24(11), 649-658.
Pinho JS, Cunliffe V, Kareklas K, Petri G & Oliveira RF () . Communications Biology, 6(1).
Jubber I, Morhardt DR, Griffin J, Cumberbatch M, Glover M, Zheng Y, Rehman I, Loynes C, Hussain SA, Renshaw SA , Leach SD et al () . Disease Models & Mechanisms.
H E, C B, VT C, M P, JD W & PJ W () . Yearbook of Paediatric Endocrinology.
Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM () . PLOS Genetics, 16(5).

Chapters

Jones A, Marson AG, Cunliffe VT, Sills GJ & Morgan A (2021) , Neuromethods (pp. 233-248). Springer US
Adwan-Shekhidem H, Atzmon G, Benayoun BA, Bowman JD, Braun KVE, Cacabelos R, Caiafa P, Cao X, Choudhury M, Chowdhury R , Ciccarone F et al (2018) , Epigenetics of Aging and Longevity (pp. xix-xxii). Elsevier

Conference proceedings papers

Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) The P450 side-chain cleavage isozyme cyp11a2 facilitates interrenal and gonadal steroid hormone biosynthesis in developing and adult zebrafish. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 66-67)
Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) Investigating the roles of androgens in male reproductive development, maintenance and function by characterisation of androgen and cortisol deficient 11 beta-hydroxylase mutant zebrafish lines. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 50-50)
Li N, Weger M, Griffin A, Eachus H, Cunliffe VT & Krone N (2018) Glucocorticoid Deficiency Causes Differentially Dysregulated Oxidative Stress Depending on the Steroidogenic Defects. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 71-72)
Oakes JA, Liz N, Wistow B, Storbeck K-H, Cunliffe VT & Krone N (2018) The Roles of Steroids in Gonadal Development and Maintenance - Insights from a Zebrafish Model of Androgen and Cortisol Deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 53-53)
Harrison MR, Georgiou AS, Lightman EG, Buckle AJ, Spaink HP & Cunliffe VT (2009) . DEVELOPMENTAL BIOLOGY, Vol. 331(2) (pp 408-408)

Preprints

Jubber I, Morhardt DR, Griffin J, Cumberbatch M, Glover M, Zheng Y, Rehman I, Loynes C, Hussain SA, Renshaw SA , Leach SD et al (2023) , Cold Spring Harbor Laboratory.
Pinho J, Cunliffe V, Petri G & Oliveira RF () , Cold Spring Harbor Laboratory.
Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM () , Cold Spring Harbor Laboratory.

Grants

Funding:

MRC
HEFCE

Collaborators:

Marysia Placzek
Penny Watt
Joseph Harrity
Val Gillet
Richard Baines
Enrico Petretto

Teaching activities

Undergraduate and postgraduate taught modules:

Undergraduate:

BMS242/243 Cell & Molecular
BMS334 Epigenetics (Coordinator)
Level 3 Practical and Dissertation Modules

Masters (MSc):

BMS6053 - Critical Analysis of Current Science

Professional activities and memberships

Organizer, EMBO Practical Courses (1999, 2004, 2007, 2010)
Postgraduate Certificate in Learning and Teaching, University of ��߲ݴ�ý (2007)
Peer reviewer for scientific journals and grant-awarding bodies
Invited speaker at international scientific meetings (European Zebrafish Meeting, International Meeting on Zebrafish Development and Genetics)

Opportunities

We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com

For further information and details of other projects on offer, please see the department PhD Opportunities page.

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School of Biosciences

School of Biosciences

Dr Vincent Cunliffe

Integration of synaptic and neuroendocrine signalling and the role of the neural epigenome in health and disease

Featured publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

Preprints

Funding:

Collaborators:

Undergraduate and postgraduate taught modules:

Links

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