Bandmann, Oliver, Professor

Professor Oliver Bandmann

MD, PhD

Neuroscience, School of Medicine and Population Health

Professor of Movement Disorders Neurology

Honorary Consultant Neurologist

Co-Director, Neuroscience Institute

o.bandmann@sheffield.ac.uk
+44 114 222 2237

+44 114 271 3005 (NHS Secretary: Kate Lovatt-Clark)

+44 114 222 2278 (Administrator: Heather Cartledge)

Room B32, ��߲ݴ�ý Institute for Translational Neuroscience (SITraN)

Full contact details

Professor Oliver Bandmann
Neuroscience, School of Medicine and Population Health
Room B32
��߲ݴ�ý Institute for Translational Neuroscience (SITraN)
385a Glossop Road
��߲ݴ�ý
S10 2HQ

Profile

2002-present: University of ��߲ݴ�ý/Royal Hallamshire Hospital, ��߲ݴ�ý, UK
1997-2002: Specialist Training in Neurology, Marburg, Germany;
1993-1997: Research Fellow, Institute of Neurology. Queen Square London. PhD on "Genetic Aspects of Parkinsonian Disorders" (Supervisors: Prof A.E. Harding, Prof C.D. Marsden, Prof N.W. Wood)
1992-1993: House officer, Dept Neurology, Klinikum Grosshadern, Munich (Head: Prof T. Brandt)
1991: Qualification at Ludwig Maximilian´s University Munich, Germany

Research interests

My research focuses on movement disorders, in particular Parkinson´s Disease (PD) but also Huntington´s Disease, Wilson Disease and dystonia. I’m particularly interested in working towards disease-modifying therapy for PD which would slow down disease progression.

The main areas of research within my group are as follows:

1. Mitochondrial dysfunction and compound screen with identification of neuroprotective compounds as candidates for disease-modifying treatment in Parkinson’s Disease:
We were the first group worldwide to undertake detailed assessment of mitochondrial function and morphology in both and . We subsequently undertook the mutant patient tissue. 2000 drugs were assessed for their rescue effect on mitochondrial function. A clear mode of action (MOA) was identified for a group of compounds which includes the FDA-licensed drug ursodeoxycholic acid (UDCA).

For interested members of the public: Please have a look at the official for more information on this project. You may also be interested in listening to a .

Fig1. The image shows a fibroblast from a patient with Parkinson’s Disease due to mutations in the parkin gene. The fibroblast has been stained to show the mitochondria in the cell. We see increased branching and interconnectedness of the mitochondrial network in the fibroblasts from patients with parkin mutations compared to controls; this change in morphology of the mitochondria correlates with changes in function.

2. Bench to bedside – early clinical trials in Parkinson’s disease

There is emerging evidence of a “Parkinson Epidemic” with a predicted global doubling in the number of people with Parkinson’s from 6 million to 12 million between 2015 and 2014 (PMID:30584159).

We have now taken UDCA as the top hit of our drug screen into an early clinical trial, called the UP study (short for: UDCA in Parkinson’s disease). The UP study will predominantly focus on investigating the safety and tolerability of UDCA in PD. However, we will also use novel techniques (in particular 31P-MR-Spectroscopy and sensor-based objective quantification of motor impairment) to gain some insight into the neuroprotective potential of UDCA.

MR Spectroscopy of a human brain with focussed analysis of the basal ganglia (the area most affected in Parkinson’s disease)

My group is also participating in two other multicentre neuroprotection trials, testing statins and antibodies against alpha-synuclein for their neuroprotective effect.
For interested members of the public: Please have a look at the official University of ��߲ݴ�ý Press release for more information on this project
/news/nr/liver-drug-trialled-in-parkinsons-patients-1.828628

This link will take you to a webpage of the Cure Parkinson’s Trust - it provides additional information on UDCA for Parkinson’s:

You may also find this video interesting during which we describe our journey from the bench at SITraN to the clinical trial carried out at the NIHR-funded Clinical Research facility at the Royal Hallamshire Hospital:

3. Zebrafish as a new vertebrate animal model for Parkinson’s Disease:

We were the first group worldwide to establish a at Bateson Centre of the University of ��߲ݴ�ý (/bateson).

We subsequently demonstrated that Parkin-deficient zebrafish share key features with human parkin-mutant Parkinson’s Disease patients, namely . Most recently, we have identified as novel mechanism leading to mitochondrial dysfunction and dopaminergic cell loss in PINK1 deficiency. Inhibition of TIGAR prevents loss of dopaminergic neurons by normalizing mitochondrial function. TIGAR is therefore a promising novel target for disease-modifying therapy in early onset Parkinson’s Disease. We are now also using zebrafish to study genetic risk factors for sporadic Parkinson’s and how they may interact with ageing.

For interested members of the public: Please have a look at the
official University of ��߲ݴ�ý press release for more information on this project.

4. Mitochondrial biomarkers in Parkinson’s Disease:
We have just completed a detailed assessment of mitochondrial and lysosomal dysfunction in patients with sporadic Parkinson’s Disease. This will hopefully allow to eventually identify those patients with Parkinson’s Disease who are most likely to benefit from medication with mitochondrial rescue drugs.

5. Huntington's Disease (HD)
We are recruiting patients for the Enroll-HD study at our multidisciplinary Huntington’s Disease clinic. As part of this, we have been frequently recruiting patients for HD drug trials and other HD studies.

6. Wilson Disease (WD)
I have previously contributed to the development of the . More recently, we have conducted the first study on the genetic prevalence of Wilson Disease in the UK in collaboration with the Welcome Sanger Institute, Cambridge, UK. This study demonstrated a surprisingly high ATP7B carrier frequency which suggests that WD may be considerably more common than previously thought. In collaboration with the ��߲ݴ�ý Diagnostic Genetics Service, we also identified .

In close collaboration with the Wilson disease patient self-help group, we have helped to establish a UK-wide, interdisciplinary Wilson disease network. This network will hopefully allow us to develop national standards for the care of Wilson disease patients and facilitate future research projects.

Publications

Journal articles

Capriglia F, Burgess T, Bandmann O & Mortiboys H (2023) . Journal of Parkinson's Disease, 13(6), 851-864.
Gonzalez-Robles C, Weil RS, van Wamelen D, Bartlett M, Burnell M, Clarke CS, Hu MT, Huxford B, Jha A, Lambert C , Lawton M et al (2023) . Journal of Parkinson's Disease, 13(6), 1011-1033.
Wason JMS & Bandmann O (2023) . Nature Reviews Drug Discovery, 22(9), 681-682.
Luxenburger A, Clemmens H, Hastings C, Harris LD, Ure EM, Cameron SA, Aasly J, Bandmann O, Weymouth-Wilson A, Furneaux RH & Mortiboys H (2023) . Biomolecules, 13(1).
Schini M, Bhatia P, Shreef H, Johansson H, Harvey NC, Lorentzon M, Kanis JA, Bandmann O & McCloskey EV (2023) . Bone, 168, 116651-116651.
Payne T, Burgess T, Sassani M, Bradley S, Roscoe S, Reed E, Wilkinson ID, Mortiboys H, Jenkins TM & Bandmann O (2022) . Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2.2-e2.2.
Shribman S, Marjot T, Sharif A, Vimalesvaran S, Ala A, Alexander G, Dhawan A, Dooley J, Gillett GT, Kelly D , McNeill A et al (2022) . The Lancet Gastroenterology & Hepatology.
Vijiaratnam N, Simuni T, Bandmann O, Morris HR & Foltynie T (2021) . The Lancet Neurology, 20(7), 559-572.
Pezzoli S, Sánchez-Valle R, Solanes A, Kempton MJ, Bandmann O, Shin JIL, Cagnin A, Goldman JG, Merkitch D, Firbank MJ , Taylor J-P et al (2021) . Neuroscience & Biobehavioral Reviews.
Pezzoli S, Cagnin A, Bussè C, Zorzi G, Fragiacomo F, Bandmann O & Venneri A (2021) . Cortex.
Brown SJ, Boussaad I, Jarazo J, Fitzgerald JC, Antony P, Keatinge M, Blechman J, Schwamborn JC, Krüger R, Placzek M & Bandmann O (2021) . Scientific Reports, 11(1).
Venneri A, Manca R, Fernandes L, Bandmann O & De Marco M (2021) . Neural Regeneration Research, 16(3), 500-500.
Shribman S, Heller C, Burrows M, Heslegrave A, Swift I, Foiani MS, Gillett GT, Tsochatzis EA, Rowe JB, Gerhard A , Butler CR et al (2021) . Movement Disorders, 36(2), 503-508.
Dewan R, Chia R, Ding J, Hickman RA, Stein TD, Abramzon Y, Ahmed S, Sabir MS, Portley MK, Tucci A , Ibáñez K et al (2021) . Neuron, 109(3), 448-460.e4.
Payne T, Sassani M, Buckley E, Moll S, Anton A, Appleby M, Maru S, Taylor R, McNeill A, Hoggard N , Mazza C et al (2020) . BMJ Open, 10(8).
Bandmann O, Weiss KH & Hedera P (2020) . Neurology, 94(21), 907-908.
Carling PJ, Mortiboys H, Green C, Mihaylov S, Sandor C, Schwartzentruber A, Taylor R, Wei W, Hastings C, Wong S , Lo C et al (2020) . Progress in Neurobiology, 187, 101772-101772.
Davis RL, Wong SL, Carling PJ, Payne T, Sue CM & Bandmann O (2020) . Neurology: Clinical Practice, 10(1), 40-46.
Davis RL, Wong SL, Carling PJ, Payne T, Sue CM & Bandmann O (2019) . Journal of Neurology Neurosurgery & Psychiatry, 90(12), e38.
Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A , Job L et al (2019) . Brain, 1-20.
Soman SK, Bazała M, Keatinge M, Bandmann O & Kuznicki J (2019) . Biology Open, 8(10).
Jabbari E, Woodside J, Tan MMX, Pavese N, Bandmann O, Ghosh BCP, Massey LA, Capps E, Warner TT, Lees AJ , Revesz T et al (2019) . Movement Disorders, 34(9), 1307-1314.
Watson L, Keatinge M, Gegg M, Bai Q, Sandulescu C, Vardi A, Futerman AH, Schapira AHV, Burton EA & Bandmann O (2019) . Neurobiology of Disease, 127, 563-569.
Ho AK, Horton MC, Landwehrmeyer GB, Burgunder J-M, Tennant A, Downie L, Jack R, Matheson K, Miedzybrodzka Z, Rae D , Simpson SA et al (2019) . Value in Health, 22(6), 712-720.
Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F, Burgunder J-M & Quarrell O (2019) . Journal of Huntington's Disease, 8(2), 181-193.
Braisch U, Muche R, Rothenbacher D, Landwehrmeyer GB, Long JD & Orth M (2019) . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180(3), 232-245.
Stafford T (2019) . Nature Scientific Reports, 9.
López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O & Highley JR (2019) . Brain Research, 1706, 218-223.
Oosterloo M, Bijlsma EK, van Kuijk SMJ, Minkels F & de Die-Smulders CEM (2019) . Parkinsonism & Related Disorders, 61, 101-105.
Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018) . Journal of Cerebral Blood Flow and Metabolism.
Bell SM, Barnes K, Clemmens H, Al-Rafiah AR, Al-ofi EA, Leech V, Bandmann O, Shaw PJ, Blackburn DJ, Ferraiuolo L & Mortiboys H (2018) . Journal of Molecular Biology, 430(21), 3942-3953.
Schöndorf DC, Ivanyuk D, Baden P, Sanchez-Martinez A, De Cicco S, Yu C, Giunta I, Schwarz LK, Di Napoli G, Panagiotakopoulou V , Nestel S et al (2018) . Cell Reports, 23(10), 2976-2988.
Williams U, Bandmann O & Walker R (2018) . Journal of Movement Disorders, 11(2), 53-64.
Taylor JC, Romanowski C, Lorenz E, Lo C, Bandmann O & Fenner J (2018) . EJNMMI Research, 8(1).
O’Malley R, Rao G, Stein P & Bandmann O (2018) . Practical Neurology, 18(5), 352-358.
Mortiboys H, Macdonald R, Payne T, Sassani M, Jenkins T & Bandmann O (2018) . FEBS Letters, 592(5), 776-792.
Reed E, Lutsenko S & Bandmann O (2018) . Journal of Neurochemistry, 146(4), 356-373.
Taylor JC, Vennart N, Negus I, Holmes R, Bandmann O, Lo C & Fenner J (2018) . Nuclear Medicine Communications, 39(3), 268-275.
McNulty P, Pilcher R, Ramesh R, Necuiniate R, Hughes A, Farewell D, Holmans P, Jones L, Bonelli RM, Hecht K , Herranhof B et al (2018) . Journal of Huntington's Disease, 7(3), 209-222.
Carling P, Mortiboys H, Mihaylov S, Clemmens H, Schwartzenhuber A, Wade-Martins R, Talbot K, Hu M & Bandmann O (2017) . Journal of Neurology, Neurosurgery & Psychiatry, 88(Suppl 1), A31.4-A32.
Baake V, Reijntjes RHAM, Dumas EM, Thompson JC & Roos RAC (2017) . Cortex, 95, 51-62.
Moss DJH, Pardiñas AF, Langbehn D, Lo K, Leavitt BR, Roos R, Durr A, Mead S, Holmans P, Jones L , Tabrizi SJ et al (2017) . The Lancet Neurology, 16(9), 701-711.
Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G , Bandmann O et al (2017) . Sleep, 40(8).
Pezzoli S, Cagnin A, Bandmann O & Venneri A (2017) . Brain Sciences, 7(7).
Bell SM, Clemmens H, Blackburn DJ, Bandmann O, Ferraiuolo L & Mortiboys H (2017) . Alzheimer's & Dementia, 13(7S_Part_26), P1269-P1269.
Lo C & Bandmann O (2017) . Handb Clin Neurol, 142, 7-17.
Soman S, Keatinge M, Moein M, DaCosta M, Mortiboys H, Skupin A, Sugunan S, Bazala M, Kuznicki J & Bandmann O (2017) . European Journal of Neuroscience, 45(4), 528-535.
Bandmann O & Chio A (2016) . Neurology.
Yealland G, Battaglia G, Bandmann O & Mortiboys H (2016) . Neuroscience Letters, 630, 23-29.
Keatinge M, Bui H, Menke A, Chen Y-C, Sokol AM, Bai Q, Ellett F, Da Costa M, Burke D, Gegg M , Trollope L et al (2015) . Human Molecular Genetics, 24(23), 6640-6652.
Mortiboys H, Furmston R, Bronstad G, Aasly J, Elliott C & Bandmann O (2015) . Neurology, 85(10), 846-852.
Bandmann O, Keatinge M, Da Costa M, Menke A, Chen Y-C & Panula P (2015) . Neurology, 84(14_supplement).
Bandmann O, Weiss KH & Kaler SG (2015) . The Lancet Neurology, 14(1), 103-113.
Robertson JD, Yealland G, Avila-Olias M, Chierico L, Bandmann O, Renshaw SA & Battaglia G (2014) . ACS Nano, 8(5), 4650-4661.
Bandmann O, Keatinge M, DaCosta M, Mortiboys H & Flinn L (2014) . Neurology, 82(10_supplement).
Bandmann O, Keatinge M, DaCosta M, Mortiboys H & Flinn L (2014) . Neurology, 82(10_supplement).
Lo C, Martindale J, Hadjivassiliou M, Martin P, Dalton A & Bandmann O (2014) . Neurogenetics, 15(1), 19-21.
Bandmann O (2013) . J Neurol Neurosurg Psychiatry, 84(11), e2.
Hubers AAM, van Duijn E, Roos RAC, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van der Mast RC & Giltay EJ (2013) . Journal of Affective Disorders, 151(1), 248-258.
Mortiboys H, Aasly J & Bandmann O (2013) . Brain, 136(Pt 10), 3038-3050.
Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R , Allen CE et al (2013) . Ann Neurol, 74(6), 837-847.
Cooper-Knock J, Frolov A, Highley JR, Charlesworth G, Kirby J, Milano A, Hartley J, Ince PG, McDermott CJ, Lashley T , Revesz T et al (2013) . Neurology, 81(9), 808-811.
Metzger S, Walter C, Riess O, Roos RAC, Nielsen JE, Craufurd D & Nguyen HP (2013) . PLoS ONE, 8(7).
Hadjivassiliou M, Aeschlimann P, Sanders DS, Mäki M, Kaukinen K, Grünewald RA, Bandmann O, Woodroofe N, Haddock G & Aeschlimann DP (2013) . Neurology, 80(19), 1740-1745.
Blackburn DJ, Alix JJP, Sarrigiannis P, Hoggard N & Bandmann O (2013) . Pract Neurol, 13(2), 114-119.
Vittori A, Orth M, Roos RAC, Outeiro TF, Giorgini F, Hollox EJ & REGISTRY investigators of the European Huntington’s Disease Network (2013) . J Huntingtons Dis, 2(1), 107-124.
Coffey AJ, Durkie M, Hague S, McLay K, Emmerson J, Lo C, Klaffke S, Joyce CJ, Dhawan A, Hadzic N , Mieli-Vergani G et al (2013) . Brain, 136(Pt 5), 1476-1487.
Berg D & Bandmann O (2013) . Neurology, 80(7), 608-609.
Vittori A, Orth M, Roos RAC, Outeiro TF, Giorgini F & Hollox EJ (2013) . Journal of Huntington's Disease, 2(1), 107-124.
Goodall EF, Heath PR, Bandmann O, Kirby J & Shaw PJ (2013) . Front Cell Neurosci, 7, 178.
Lo C, Flinn LJ & Bandmann O (2013) . Neurosci Lett, 532, 55-58.
Lee J-M, Ramos EM, Lee J-H, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA , Margolis RL et al (2012) . Neurology, 78(10), 690-695.
Bandmann O & Cookson MR (2012) . Neurology, 78(11), 772-773.
Quarrell O, O'Donovan KL, Bandmann O & Strong M (2012) . PLoS Curr, 4, e4f8606b742ef3.
Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline M & Landwehrmeyer GB (2012) . European Journal of Human Genetics, 20(1), 20-26.
Alvarez-Fischer D, Grundmann M, Lu L, Samans B, Fritsch B, Möller JC, Schaefer MK-H, Hartmann A, Oertel WH & Bandmann O (2012) Prolonged generalized dystonia after chronic cerebellar application of kainic acid. Brain Research.
Alvarez-Fischer D, Grundmann M, Lu L, Samans B, Fritsch B, Möller JC, Schaefer MKH, Hartmann A, Oertel WH & Bandmann O (2012) . Brain Research, 1464, 82-88.
Orth M (2011) . Journal of Neurology, Neurosurgery & Psychiatry, 82(12), 1409-1412.
Bretaud S, MacRaild S, Ingham PW & Bandmann O (2011) . Zebrafish, 8(3), 103-108.
Mortiboys H, Johansen KK, Aasly JO & Bandmann O (2010) . Neurology, 75(22), 2017-2020.
Bandmann O & Burton EA (2010) . Neurobiol Dis, 40(1), 58-65.
Cookson MR & Bandmann O (2010) . Hum Mol Genet, 19(R1), R21-R27.
Wignall EL, Griffiths PD, Papadakis NG, Wilkinson ID, Wallis LI, Bandmann O, Cowell PEE & Hoggard N (2010) . AM J NEURORADIOL, 31(5), 856-861.
Aziz NA, Jurgens CK, Landwehrmeyer GB, van Roon-Mom WMC, van Ommen GJB, Stijnen T & Roos RAC (2009) . Neurology, 73(16), 1280-1285.
Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O & Whitworth AJ (2009) . Nat Neurosci, 12(9), 1129-1135.
Flinn L, Mortiboys H, Volkmann K, Köster RW, Ingham PW & Bandmann O (2009) . Brain, 132(Pt 6), 1613-1623.
Mortiboys H, Thomas KJ, Koopman WJH, Klaffke S, Abou-Sleiman P, Cookson MR & Bandmann O (2009) . Mitochondrion, 9(1), 63-63.
Mortiboys H, Thomas KJ, Koopman WJH, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PHGM, Smeitink JAM, Cookson MR & Bandmann O (2008) . Ann Neurol, 64(5), 555-565.
Flinn L, Bretaud S, Lo C, Ingham PW & Bandmann O (2008) . J Neurochem, 106(5), 1991-1997.
Bandmann O & Singleton AB (2008) . Neurology, 71(8), 542-543.
Möller JC, Tackenberg B, Heinzel-Gutenbrunner M, Burmester R, Oertel WH, Bandmann O & Müller-Vahl KR (2008) . Eur J Neurol, 15(7), 749-753.
Hedera P & Bandmann O (2008) . Neurology, 70(16 Pt 2), 1375-1376.
Leinweber B, Möller JC, Scherag A, Reuner U, Günther P, Lang CJG, Schmidt HHJ, Schrader C, Bandmann O, Czlonkowska A , Oertel WH et al (2008) . Mov Disord, 23(1), 54-62.
Bretaud S, Allen C, Ingham PW & Bandmann O (2007) . J Neurochem, 100(6), 1626-1635.
Czlonkowska A, Tarnacka B, Moller JC, Leinweber B, Oertel WH, Bandmann O & Woimant F (2007) Unified Wilson's Disease Rating Scale (UWDRS) - a proposal for the neurological scoring of Wilson's disease patients. PARKINSONISM RELAT D, 13, S80-S80.
Członkowska A, Tarnacka B, Möller JC, Leinweber B, Bandmann O, Woimant F & Oertel WH (2007) Unified Wilson's Disease Rating Scale - a proposal for the neurological scoring of Wilson's disease patients.. Neurol Neurochir Pol, 41(1), 1-12.
Tackenberg B, Möller JC, Rindock H, Bien S, Sommer N, Oertel WH, Rosenow F, Schepelmann K, Hamer HM & Bandmann O (2006) . Neurology, 67(12), 2250-2252.
Möller JC, Leinweber B, Rissling I, Oertel WH, Bandmann O & Schmidt HH-J (2006) . Mov Disord, 21(10), 1789-1790.
Klaffke S, König IR, Poustka F, Ziegler A, Hebebrand J & Bandmann O (2006) . Mov Disord, 21(6), 881-883.
Hague S, Klaffke S, Clarimon J, Hemmer B, Singleton A, Kupsch A & Bandmann O (2006) . Neurology, 66(6), 951-952.
Kamm C, Healy DG, Quinn NP, Wüllner U, Moller JC, Schols L, Geser F, Burk K, Børglum AD, Pellecchia MT , Tolosa E et al (2005) . Brain, 128(Pt 8), 1855-1860.
Hague SM, Klaffke S & Bandmann O (2005) . J Neurol Neurosurg Psychiatry, 76(8), 1058-1063.
Asmus F, Schoenian S, Lichtner P, Munz M, Mayer P, Muller-Myhsok B, Zimprich A, Remschmidt H, Hebebrand J, Bandmann O & Gasser T (2005) . Neurogenetics, 6(1), 55-56.
Rissling I, Geller F, Bandmann O, Stiasny-Kolster K, Körner Y, Meindorfner C, Krüger H-P, Oertel WH & Möller JC (2004) . Mov Disord, 19(11), 1279-1284.
Bandmann O (2004) Advances in dystonia. EUR J NEUROL, 11, 1-1.
Grundmann M, Earl CD, Sautter J, Henze C, Oertel WH & Bandmann O (2004) . Exp Neurol, 187(1), 199-202.
Möller JC, Depboylu C, Kölsch H, Lohmüller F, Bandmann O, Gocke P, Du Y, Paus S, Wüllner U, Gasser T , Oertel WH et al (2004) . Neurosci Lett, 359(3), 195-197.
Bandmann O (2004) . Neurology, 62(3), 357-358.
Stiasny-Kolster K, Möller JC, Zschocke J, Bandmann O, Cassel W, Oertel WH & Hoffmann GF (2004) . Mov Disord, 19(2), 192-196.
Sibbing D, Asmus F, König IR, Tezenas du Montcel S, Vidailhet M, Sangla S, Oertel WH, Brice A, Ziegler A, Gasser T & Bandmann O (2003) . Neurology, 61(8), 1097-1101.
Schoenian S, Konig I, Oertel W, Remschmidt H, Ziegler A, Hebebrand J & Bandmann O (2003) . Am J Med Genet B Neuropsychiatr Genet, 119B(1), 60-64.
Bandmann O, Goertz M, Zschocke J, Deuschl G, Jost W, Hefter H, Müller U, Zöfel P, Hoffmann G & Oertel W (2003) . Neurology, 60(4), 700-702.
Sibbing D, Trender-Gerhardt I, Wood NW, Oertel WH, Bhatia KP & Bandmann O (2003) . Ann Neurol, 53(2), 278-279.
Teepker M, Hamer HM, Knake S, Bandmann O, Oertel WH & Rosenow F (2002) Myoclonic encephalopathy caused by chronic bismuth abuse.. Epileptic Disord, 4(4), 229-233.
Bandmann O, Asmus F, Sibbing D, Grundmann M, Schwab SG, Müller J, Wildenauer DB, Poewe W, Gasser T & Oertel WH (2002) . Neurology, 59(5), 782-783.
Asmus F, Zimprich A, Tezenas S, Bandmann O, Kupsch A, Kabus C, Ziemann U, Schoels L, Deuschl G, Valente EM , Durr A et al (2002) Spectrum of mutations in the gene for epsilon-sarcoglycan (SGCE) in myoclonus-dystonia syndrome (MDS, DYT11). NEUROLOGY, 58(7), A17-A17.
Arnold G, Schwarz J, Tatsch K, Kraft E, Wächter T, Bandmann O & Oertel WH (2002) . J Neural Transm (Vienna), 109(4), 503-512.
Bandmann O & Wood NW (2002) . Neuropediatrics, 33(1), 1-5.
Bandmann O, Vaughan JR, Holmans P, Marsden CD & Wood NW (2000) Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.. Mov Disord, 15(1), 30-35.
Immisch I, Bandmann O, Quintern J & Straube A (1999) . Eur J Neurol, 6(5), 549-554.
Morris HR, Janssen JC, Bandmann O, Daniel SE, Rossor MN, Lees AJ & Wood NW (1999) . J Neurol Neurosurg Psychiatry, 66(5), 665-667.
Möller JC, Bandmann O & Oertel WH (1999) . Dtsch Med Wochenschr, 124(8), 219-222.
Robinson R, McCarthy GT, Bandmann O, Dobbie M, Surtees R & Wood NW (1999) . J Neurol Neurosurg Psychiatry, 66(1), 86-89.
Oertel WH & Bandmann O (1999) . J Neural Transm Suppl, 56, 155-164.
Bandmann O, Vaughan J, Holmans PA, Marsden CD & Wood NW (1999) Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2.. Adv Neurol, 80, 199-204.
Bandmann O, Valente EM, Holmans P, Surtees RA, Walters JH, Wevers RA, Marsden CD & Wood NW (1998) . Ann Neurol, 44(4), 649-656.
Vaughan J, Durr A, Tassin J, Bereznai B, Gasser T, Bonifati V, De Michele G, Fabrizio E, Volpe G, Bandmann O , Johnson WG et al (1998) . Ann Neurol, 44(2), 270-273.
Bandmann O & Oertel WH (1998) Mental disorders in movement disorders. CURR OPIN PSYCHIATR, 11(3), 315-319.
Bandmann O, Marsden CD & Wood NW (1998) . Mov Disord, 13(2), 203-211.
Bandmann O & Wood NW (1998) Acetylator genotype and Parkinson's disease - Reply. LANCET, 351(9096), 142-142.
Paolini M, Nicholl DJ, Bennett P, Bandmann O & Wood NW (1998) . Lancet, 351(9096), 141-142.
Bandmann O, Marsden CD & Wood NW (1998) Atypical presentations of dopa-responsive dystonia.. Adv Neurol, 78, 283-290.
Bandmann O, Sweeney MG, Daniel SE, Wenning GK, Quinn N, Marsden CD & Wood NW (1997) . Neurology, 49(6), 1598-1604.
Bandmann O, Vaughan J, Holmans P, Marsden CD & Wood NW (1997) . Lancet, 350(9085), 1136-1139.
Jarman PR, Bandmann O, Marsden CD & Wood NW (1997) . J Neurol Neurosurg Psychiatry, 63(3), 304-308.
Bandmann O, Sweeney MG, Daniel SE, Marsden CD & Wood NW (1997) . J Neurol, 244(4), 262-265.
Bandmann O, Daniel S, Marsden CD, Wood NW & Harding AE (1996) . J Neurol Sci, 141(1-2), 27-32.
Bandmann O, Davis MB, Marsden CD & Wood NW (1996) . Neuroscience, 72(4), 877-879.
Chalmers RM, Bandmann O & Harding AE (1996) . J Neurol Neurosurg Psychiatry, 60(5), 588.
Bandmann O, Nygaard TG, Surtees R, Marsden CD, Wood NW & Harding AE (1996) . Hum Mol Genet, 5(3), 403-406.
Schwarz J, Weis S, Kraft E, Tatsch K, Bandmann O, Mehraein P, Vogl T & Oertel WH (1996) . J Neurol Neurosurg Psychiatry, 60(1), 98-101.
Oertel WH, Bandmann O, Eichhorn T & Gasser T (1996) Peripheral markers in Parkinson's disease. An overview.. Adv Neurol, 69, 283-291.
Bandmann O, Wenning GK, Quinn NP & Harding AE (1995) . J Neurol Neurosurg Psychiatry, 59(5), 557.
Bandmann O, Davis MB, Marsden CD & Harding AE (1995) . J Neurol Neurosurg Psychiatry, 59(1), 90-91.
Planté-Bordeneuve V, Bandmann O, Wenning G, Quinn NP, Daniel SE & Harding AE (1995) . Mov Disord, 10(3), 277-278.
Oertel WH, Trenkwalder C, Gasser T, Schwarz J, Bucher SF, Eichhorn T, Pogarell O, Künig G, Arnold G & Bandmann O (1995) Epidemiological, genetic, pharmacological, kinesiological, nuclear medical (IBZM-SPECT), standard and functional MRI studies on Parkinson's disease and related disorders and economic evaluation of Parkinson's disease therapy--clinical projects in the BMFT-research program Munich: "Parkinson's disease and other basal ganglia disorders".. J Neural Transm Suppl, 46, 325-337.
Rubinsztein DC, Hanlon CS, Irving RM, Goodburn S, Evans DG, Kellar-Wood H, Xuereb JH, Bandmann O & Harding AE (1994) . Mol Cell Probes, 8(6), 519-525.
Straube A, Bandmann O, Büttner U & Schmidt H (1993) . Headache, 33(8), 446-448.
Arnold G, Bondy B, Bandmann O, Gasser T, Schwarz J, Trenkwalder C, Wagner M, Poewe W & Oertel WH (1993) . J Neural Transm Park Dis Dement Sect, 5(2), 107-116.
Arena G, Landoulsi Z, Grossmann D, Payne T, Vitali A, Delcambre S, Baron A, Antony P, Boussaad I, Bobbili DR , Sreelatha AAK et al () . Annals of Neurology.
Payne T, Burgess T, Bradley S, Roscoe S, Sassani M, Dunning MJ, Hernandez D, Scholz S, McNeill A, Taylor R , Su L et al () . Brain.
Mihaylov SR, Castelli LM, Lin Y-H, Gül A, Soni N, Hastings C, Flynn HR, Păun O, Dickman MJ, Snijders AP , Goldstone R et al () . Nature Communications, 14(1).
Payne T, Appleby M, Buckley E, van Gelder LMA, Mullish BH, Sassani M, Dunning MJ, Hernandez D, Scholz SW, McNeill A , Libri V et al () . Movement Disorders.
Keatinge M, Gegg ME, Watson L, Mortiboys H, Li N, Dunning M, Ailani D, Bui H, van Rens A, Lefeber DJ , Schapira AHV et al () . Disease Models & Mechanisms.
Foltynie T, Gandhi S, Gonzalez-Robles C, Zeissler M-L, Mills G, Barker R, Carpenter J, Schrag A, Schapira A, Bandmann O , Mullin S et al () . Brain.
Shribman S, Burrows M, Convery R, Bocchetta M, Sudre CH, Acosta‐Cabronero J, Thomas DL, Gillett GT, Tsochatzis EA, Bandmann O , Rohrer JD et al () . Movement Disorders.
Larbalestier H, Keatinge M, Watson L, White E, Gowda S, Wei W, Koler K, Semenova SA, Elkin AM, Rimmer N , Sweeney ST et al () . The Journal of Neuroscience.
Shribman S, Poujois A, Bandmann O, Czlonkowska A & Warner TT () . Journal of Neurology, Neurosurgery & Psychiatry.
Shribman S, Bocchetta M, Sudre CH, Acosta-Cabronero J, Burrows M, Cook P, Thomas DL, Gillett GT, Tsochatzis EA, Bandmann O , Rohrer JD et al () . Brain.
Shahi MS, Chowdhury TI, Bandmann O & Jenkins T () . Practical Neurology.
Saft C, Epplen JT, Wieczorek S, Landwehrmeyer GB, Roos RAC, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D & Arning L () . PLoS Currents, 3, RRN1247-RRN1247.
Delatycki MB & Bandmann O () . Neurology, 87(3), 247-248.
Mortiboys HJ, Cox A, Brock IW & Bandmann O () The common PARK8 mutation LRRK2 G2019S is not a risk factor for breast cancer in the absence of Parkinson's disease.. Journal of Neurology.

Chapters

Hague SM, Klaffke S & Bandmann O (2006) , Neuroscience for Neurologists (pp. 181-200). PUBLISHED BY IMPERIAL COLLEGE PRESS AND DISTRIBUTED BY WORLD SCIENTIFIC PUBLISHING CO.

Conference proceedings papers

Gonzalez-Robles C, Byrom D, Chapman R, Dexter D, Duty S, Ellis-Doyle R, Jabbari E, Mills G, Mortiboys H, Rudiger J , Sammler E et al (2022) Treatment Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease: The Search for the Ideal Neuroprotective Drug. MOVEMENT DISORDERS, Vol. 37 (pp S329-S329)
Payne T, Burgess T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson I, Mortiboys H, Jenkins T & Bandmann O (2022) Multimodal mechanistic disease stratification in sporadic Parkinson's disease. MOVEMENT DISORDERS, Vol. 37 (pp S113-S113)
Payne T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson I, Mortiboys H, Jenkins T & Bandmann O (2021) Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson's disease. MOVEMENT DISORDERS, Vol. 36 (pp S370-S371)
Payne T, Sassani M, Roscoe S, Bradley S, Anton A, Reed E, Wilkinson ID, Mortiboys H, Jenkins TM & Bandmann O (2021) (31)Phosphorus Magnetic Resonance Spectroscopy as a Tool to Identify Mitochondrial Dysfunction in Parkinson's Disease In-Vivo. ANNALS OF NEUROLOGY, Vol. 90 (pp S152-S153)
Payne T, Appleby M, Buckley E, Mazza C, Foltynie T & Bandmann O (2020) The UP study - Ursodeoxycholic acid (UDCA) as neuroprotective treatment for Parkinson's disease. MOVEMENT DISORDERS, Vol. 35 (pp S413-S414)
Bandmann O (2019) Disease-modifying treatment in Parkinson's disease - opportunities and obstacles. FEBS OPEN BIO, Vol. 9 (pp 40-40)
Bandmann S, Keatinge M, Placzek M & Bandmann O (2018) Adult neurogenesis is impaired in pink1-/- zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 33 (pp S605-S605)
Keatinge M, Trollope L, Mortiboys H & Bandmann O (2018) Acid sphingomyelinase deficiency rescues mitochondrial dysfunction in gba-/- zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 33 (pp S615-S615)
Taylor J, Kinsella M, Yong Y, Azam I, Balachandar R, Balian V, King M, Lo C, Bandmann O & Fenner J (2017) Impact of Computer Aided Diagnosis (CAD) on DaTSCAN reporting: a pilot study. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol. 44 (pp S611-S611)
Robles-Lopez KL, Bandmann O & Highley JR (2016) The role of TIGAR in Parkinson's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol. 42 (pp 34-35)
Payne T, Keatinge M, Costa MD & Bandmann O (2015) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.93-e4)
Keatinge M, DaCosta M, Menke A, Chen Y-C, Bui HH, O'Neill M & Bandmann O (2015) . Journal of Neurology, Neurosurgery & Psychiatry, Vol. 86(11) (pp e4.46-e4)
Dong B, Shao L, Da Costa M, Bandmann O & Frangi AF (2015) . 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI), 16 April 2015 - 19 April 2015.
Dong B, Shao L, Frangi AF, Bandmann O & Costa MD (2014) . 2014 22nd International Conference on Pattern Recognition, 24 August 2014 - 28 August 2014.
Bandmann O, Keatinge M, Flinn L & DaCosta M (2014) TIGAR inactivation rescues dopaminergic neurons in parkin deficiency. MOVEMENT DISORDERS, Vol. 29(14) (pp 1839-1840)
Bandmann O, Keatinge M, Flinn L & DaCosta M (2014) TIGAR inactivation rescues dopaminergic neurons in parkin deficiency. MOVEMENT DISORDERS, Vol. 29 (pp S3-S3)
Cooper-Knock J, Highley JR, Hartley J, Milano A, Sawcer S, Compston A, Frolov A, Charlesworth G, Wood N, Bandmann O , McDermott CJ et al (2013) Neurodegeneration caused by intronic expansions of C9ORF72 is a clinically heterogeneous but pathologically distinct disease. LANCET, Vol. 381 (pp 32-32)
Blackburn D, Alix JP & Bandmann O (2012) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83
Bandmann O, Johansen KK, Aasly JO & Mortiboys H (2010) Mitochondrial Impairment in Manifesting LRRK2-G2019S Carriers. NEUROLOGY, Vol. 74(9) (pp A255-A255)
Kuhl JS, Kohler W, Bandmann O, Buchholz S, Hemmati P, Snowden J, Sokolowski P, Stadler M, Terwey T & Arnold R (2009) Bone marrow transplantation in adult cerebral X-linked adrenoleukodystrophy: an update. BONE MARROW TRANSPLANTATION, Vol. 43 (pp S182-S183)
Flinn L, Mortiboys H, Volkmann K, Koester RW, Ingham PW & Bandmann O (2009) Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). MOVEMENT DISORDERS, Vol. 24 (pp S135-S135)
Bandmann O, Klaffke S, Sleiman P, Wood NW & Mortiboys HJ (2008) Abnormal mitochondrial function and morphology in fibroblasts of patients with early onset Parkinson's disease and two parkin mutations. NEUROLOGY, Vol. 70(11) (pp A485-A485)
Mortiboys H, Thomas K, Klaffke S, Koopman W, Cookson M & Bandmann O (2008) Mitochondrial function and morphology in parkin mutant fibroblasts. MOVEMENT DISORDERS, Vol. 23(1) (pp S49-S49)
Bandmann O, Bretaud S, Allen CE & Ingham PW (2007) P53 dependent neuronal cell death in a DJ-1 deficient zebrafish model of Parkinson disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 78(9) (pp 1024-1024)
Tackenberg B, Moeller C, Rindock H, Beyer TF, Sommer N, Oertel WH, Rosenow F, Schepelmann K, Hamer HM & Bandmann O (2005) Proximal and central myelin damage of cranial nerves in hereditary neuropathy with liability to pressure palsies. NEUROLOGY, Vol. 64(6) (pp A376-A376)
Moller C, Tackenberg B, Muller-Vahl K, Heinzel-Gutenbrunner M, Oertel WH & Bandmann O (2004) Immunocytological analysis of B-, T-, and natural killer cell subsets in Tourette syndrome. MOVEMENT DISORDERS, Vol. 19 (pp S439-S439)
Klaffke S, Koenig L, Ziegler A, Hebebrand J & Bandmann O (2004) The Va166Met polymorphism of the brain derived neurotrophic factor (BDNF): A shared genetic risk factor for obsessive-compulsive behaviour and Gilles de la Tourette syndrome?. MOVEMENT DISORDERS, Vol. 19 (pp S354-S354)
Rissling I, Bandmann O, Hoft C, Burmester R, Oertel WH & Moller C (2004) Prevalence of UCHL1, DJ1 and NR4A2 gene mutations in young-onset Parkinson's disease (YOPD) patients. MOVEMENT DISORDERS, Vol. 19 (pp S358-S358)
Asmus F, Schoenian S, Lichtner P, Mueller-Myhsok B, Bandmann O & Gasser T (2004) The role of the epsilon-sarcoglycan gene (SGCE) in Gilles de la Tourette patients. MOVEMENT DISORDERS, Vol. 19 (pp S363-S363)
Schuele R, de Montcel ST, Brice A, Bandmann O, Gasser T & Asmus F (2004) Evaluation of the epsilon-sarcoglyan (SGCE) promoter region in myoclonus-dystonia (M-D). MOVEMENT DISORDERS, Vol. 19 (pp S96-S97)
Alvarez-Fischer D, Grundmann M, Lu L, Moller C, Oertel WH & Bandmann O (2004) Gene expression studies in a novel rat dystonia model. MOVEMENT DISORDERS, Vol. 19 (pp S98-S98)
Stiasny-Kolster K, Mignot E, Ling L, Moller JC, Bandmann O, Cassel W, Oertel WH & Hoffmann JG (2003) The role of CNS dopaminergic, serotonergic and hypocretin (Orexin) systems in restless legs syndrome. SLEEP, Vol. 26 (pp A325-A326)
Bandmann O, Schoenian S, Koenig I, Remschmidt H, Ziegler A & Oertel W (2002) Tourette syndrome and attention deficit hyperactivity disorder: Are there shared genetic susceptibility factors?. MOVEMENT DISORDERS, Vol. 17 (pp S342-S342)
Rissling I, Moller JC, Korner Y, Bandmann O, Stiasny K & Oertel WH (2002) Dopamine receptor and hypocretin gene polymorphisms in Parkinson's disease (PD) patients reporting "sleep attacks". MOVEMENT DISORDERS, Vol. 17 (pp S138-S138)
Bandmann O, Sibbing D, Asmus F, Koenig I, Grundmann M & Ziegler A (2002) Candidate gene research in focal dystonia excludes involvement of ATP7A, ATP7B, ATOX, HLA-DR and MTHFR. MOVEMENT DISORDERS, Vol. 17 (pp S278-S279)

Preprints

Mihaylov SR, Castelli LM, Lin Y-H, Gül A, Soni N, Hastings C, Flynn HR, Dickman MJ, Snijders AP, Bandmann O , Mortiboys H et al () , Cold Spring Harbor Laboratory.
Keatinge M, Gegg ME, Watson L, Mortiboys H, Bui H, Lefeber D, Rens AV, MacDonald R, Schapira A & Bandmann O () , Research Square Platform LLC.
Keatinge M, Gegg ME, Watson L, Mortiboys H, Li N, Dunning M, Ailani D, Bui H, van Rens A, Lefeber DJ , MacDonald RB et al () , Cold Spring Harbor Laboratory.
Bannard C, Leriche M, Bandmann O, Brown C, Ferracane E, Sánchez-Ferro A, Obeso J, Redgrave P & Stafford T () , Center for Open Science.

Research group

Clinical Fellows: Dr Tom Payne, Dr Emily Reed
UP study Trial Manager: Sarah Moll (co-funded by ��߲ݴ�ý Neuroscience BRC)
Post-doctoral scientists: Dr Lisa Watson (ne Trollope), Dr Deepak Ailandi
PhD students as primary supervisor: Mohammed Karami, Hannah Larbalestier, Emma White

Co-supervision with Dr Heather Mortiboys:

Postdoctoral scientist: Dr Helen Rowland
PhD students: Chris Hastings, Ruby McDonald, Rachel Hughes
Technician: Sarah Roscoe

Grants

The UP Study is predominantly funded by the JP Moulton Foundation, but also supported by Cure Parkinson’s UK and the ��߲ݴ�ý Neuroscience BRC.

My research is also supported by the Medical Research Council (MRC), the Michael J Fox Foundation (MJFF) and the University of ��߲ݴ�ý. In the past, I’ve also had substantial funding from Parkinson’s UK.

Teaching interests

I was the Dept Neuroscience Undergraduate Teaching Lead/Director for Teaching and Learning for 15 years (2002-2017). I was also the University of ��߲ݴ�ý BMedSci Programme Director for 5 years (2013-2018).

I twice won the “Consultant Teacher of the Year" award of the ��߲ݴ�ý Medical Student Society MedSoc.

I continue to contribute to all undergraduate phases of our MBChB course and also contribute to SITRaN-based MSc courses.

I am now the academic training lead for the STH Neuroscience Directorate and also the Training Lead for our NIHR-funded ��߲ݴ�ý Neuroscience BRC.

Professional activities and memberships

Member of the Editorial Board of the clinical Neuroscience Journals NEUROLOGY and Parkinsonism& Related Disorders
Member of the MRC-DPFS Panel
Deputy Chair of Association of British Neurologists (ABN) Research Committee
Chair of the ABN Movement Disorders Advisory Group
Movement Disorders Theme Lead of STH Academic Neuroscience Directorate and the NIHR-funded ��߲ݴ�ý Neuroscience BRC

Awards and esteem factors

1984-1991: Bavarian Scholarship for highly gifted students
1986-1991: German Scholarship for highly gifted students ("Studienstiftung des Deutschen Volkes")
1993-1997: Training Fellowship of Deutsche Forschungsgemeinschaft (DFG)
1996: Presidents Prize of Royal Society of Medicine
1997: Queen Square Prize of Institute of Neurology
2000: Oppenheim Prize of German Dystonia Society
2006: "Consultant Teacher of the Year" Prize of "Med Soc" (organization of medical students at UoS Medical School)

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School of Medicine and Population Health