Livesey, Matthew , Dr

Dr Matthew Livesey

PhD

Neuroscience, School of Medicine and Population Health

Research Fellow

M.R.Livesey@��߲ݴ�ý.ac.uk
+44 114 222 2233

��߲ݴ�ý Institute for Translational Neuroscience (SITraN)

Full contact details

Dr Matthew Livesey
Neuroscience, School of Medicine and Population Health
��߲ݴ�ý Institute for Translational Neuroscience (SITraN)
385a Glossop Road
��߲ݴ�ý
S10 2HQ

Profile

I studied Pharmacology (B.Sc. Hons) at the University of Edinburgh between 2001 – 2005. In 2005, I joined the Department of Neuroscience, University of Dundee, to undertake a BBSRC-Case PhD studentship. Here, using patch-clamp electrophysiology techniques, I examined the structure-function of pentameric ligand-gated ion channels. My time in Dundee included a short post-doctoral position (JBC, 2008 and JBC, 2011).

I joined the University of Edinburgh at the start of 2011 and undertook a postdoctoral position to examine the functional capabilities and developmental properties of pluripotent stem cell-derived cortical neurons (J.Neurosci, 2014; J.Physiol, 2014 and PLoS One, 2014). In this time I became interested in using this technology in order to model disease, specifically amyotrophic lateral sclerosis and frontotemporal dementia, and was awarded a Royal Society of Edinburgh Fellowship (2015) in order to investigate synaptic impairments in ALS-FTD (Nature Neuroscience, 2016; Nature Communications, 2018; J.Pathology, 2020; Molecular Neurodegeneration, 2021). Furthermore, noting the increasing appreciation of the roles of non-neuronal cell types in healthy neuronal health and disease, I have also explored the functional properties of oligodendrocytes-derived from ALS patients (Stem Cells, 2016) and also began to examine the heavily underexplored area of oligodendrocyte physiology (Glia, 2019; Journal of Neuroscience, 2021).

In March 2020, I arrived at SITraN as a principle investigator to lead work on neurophysiological perturbations and their mechanistic bases in ALS-FTD.

Research interests

In neurodegenerative disease, neuronal dysfunction precedes neuronal death. My research interests centre around understanding these functional disturbances in neurons. Furthermore, it is increasingly regarded that such diseases are not ‘purely’ neuronal and often include a role for their supporting cells called glia. Our research also therefore investigates the properties of glia; both their functional properties and their role on neuronal function.

To do this we combine multiple research specialisations; electrophysiology, human in vitro cell models and rodent models.

Current Projects

Glutamatergic dysfunction in ALS patient-derived neurons and glia.
Synaptic pathophysiology in cortical neurons derived from ALS patients.
The physiological role of C9ORF72.
The role of ion channels on oligodendrocyte-lineage cell function.

Publications

Journal articles

Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS , Ning K et al (2022) . Neuron.
Pasniceanu I-S, Atwal MS, Souza CDS, Ferraiuolo L & Livesey MR (2021) . Frontiers in Cellular Neuroscience, 15.
Barton SK, Magnani D, James OG, Livesey MR, Selvaraj BT, James OT, Perkins EM, Gregory JM, Cleary E, Ausems CRM , Carter R et al (2021) . Brain Communications, 3(4).
Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Lin Y-H, Myszczynska MA, Heath PR, Livesey MR, Ning K , Azzouz M et al (2021) . Molecular Neurodegeneration, 16(1).
Swire M, Assinck P, McNaughton PA, Lyons DA, ffrench-Constant C & Livesey MR (2021) . The Journal of Neuroscience.
Perkins EM, Burr K, Banerjee P, Mehta AR, Dando O, Selvaraj BT, Suminaite D, Nanda J, Henstridge CM, Gillingwater TH , Hardingham GE et al (2021) . Molecular Neurodegeneration, 16(1).
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR , Bassell GJ et al (2020) . Molecular Autism, 11(1).
Marshall-Phelps KLH, Kegel L, Baraban M, Ruhwedel T, Almeida RG, Rubio-Brotons M, Klingseisen A, Benito-Kwiecinski SK, Early JJ, Bin JM , Suminaite D et al (2020) . Journal of Cell Biology, 219(7).
Gregory JM, Livesey MR, McDade K, Selvaraj BT, Barton SK, Chandran S & Smith C (2020) . The Journal of Pathology, 250(1), 67-78.
Gregory JM, McDade K, Livesey MR, Croy I, Marion de Proce S, Aitman T, Chandran S & Smith C (2020) . Neuropathology and Applied Neurobiology, 46(5), 441-457.
Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al (2019) . Molecular Psychiatry, 24(11), 1567-1567.
Suminaite D, Lyons DA & Livesey MR (2019) . Glia, 67(11), 2050-2062.
Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al (2019) . Molecular Psychiatry, 24(11), 1641-1654.
Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG , Livesey MR et al (2019) . Molecular Psychiatry, 24(2), 294-311.
Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O , Lillico SG et al (2018) . Nature Communications, 9(1).
Etherington L-A, Mihalik B, Pálvölgyi A, Ling I, Pallagi K, Kertész S, Varga P, Gunn BG, Brown AR, Livesey MR , Monteiro O et al (2017) . Neuropharmacology, 125, 353-364.
Selvaraj BT, Livesey MR & Chandran S (2017) . Brain Pathology, 27(4), 518-524.
Johnstone M, Vasistha N, Livesey M, Burr K, Whalley H, Clair DS, Blackwood D, Wyllie D, Lawrie S, Johnstone EC , McIntosh AM et al (2017) . European Neuropsychopharmacology, 27, S509-S510.
Livesey MR, Magnani D, Hardingham GE, Chandran S & Wyllie DJA (2016) . The Journal of Physiology, 594(22), 6573-6582.
Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S , Burr K et al (2016) .
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D , Sadegh C et al (2016) . Nature Neuroscience, 19(4), 542-553.
Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC , Hardingham GE et al (2016) . STEM CELLS, 34(4), 1040-1053.
Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE & Chandran S (2016) . The Lancet, 387, S88-S88.
Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE & Chandran S (2016) . EBioMedicine, 3, 141-154.
James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S , Kind PC et al (2014) . The Journal of Physiology, 592(19), 4353-4363.
Sharma R, Livesey MR, Wyllie DJA, Proudfoot C, Whitelaw CBA, Hay DC & Donadeu FX (2014) . Stem Cells and Development, 23(13), 1524-1534.
Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S & Wyllie DJA (2014) . Journal of Neuroscience, 34(11), 4070-4075.
Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA & Lambert JJ (2013) . Journal of Biological Chemistry, 288(44), 31592-31601.
Wyllie DJA, Livesey MR & Hardingham GE (2013) . Neuropharmacology, 74, 4-17.
Edman S, McKay S, MacDonald LJ, Samadi M, Livesey MR, Hardingham GE & Wyllie DJA (2012) . Neuropharmacology, 63(3), 441-449.
Chia PW, Livesey MR, Slawin AMZ, van Mourik T, Wyllie DJA & O'Hagan D (2012) . Chemistry - A European Journal, 18(28), 8813-8819.
Livesey MR, Cooper MA, Lambert JJ & Peters JA (2011) . Journal of Biological Chemistry, 286(18), 16008-16017.
Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG & Lambert JJ (2010) . The Journal of Physiology, 588(4), 587-596.
Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ & Peters JA (2008) . Journal of Biological Chemistry, 283(28), 19301-19313.
Chen PE, Geballe MT, Katz E, Erreger K, Livesey MR, O'Toole KK, Le P, Lee CJ, Snyder JP, Traynelis SF & Wyllie DJA (2008) . The Journal of Physiology, 586(1), 227-245.
Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA & Hales TG (2007) . Journal of Biological Chemistry, 282(9), 6172-6182.
Peters JA, Carland JE, Cooper MA, Livesey MR, Deeb TZ, Hales TG & Lambert JJ (2006) . Biochemical Society Transactions, 34(5), 882-886.
Bin J, Suminaite D, Benito-Kwiecinski S, Kegel L, Rubio-Brotons M, Early J, Soong D, Livesey M, Poole R & Lyons D () Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons. Nature Communications.
Bauer CS, Cohen RN, Sironi F, Livesey MR, Gillingwater TH, Highley JR, Fillingham DJ, Coldicott I, Smith EF, Gibson YB , Webster CP et al () . Acta Neuropathologica.
Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al () . Human Molecular Genetics.
Madden ME, Suminaite D, Ortiz E, Early JE, Koudelka S, Livesey MR, Bianco IH, Granato M & Lyons DA () . The Journal of Neuroscience.
Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJA & Chandran S () . PLoS ONE, 9(1), e85932-e85932.
Vasistha NA, Johnstone M, Barton SK, Mayerl S, Selvaraj BT, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME , Livesey MR et al () .
Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S , Burr K et al () . eLife, 5.

Chapters

Magnani D, Chandran S, Wyllie DJA & Livesey MR (2019) , Oligodendrocytes (pp. 65-77). Springer New York

Preprints

Chen H-JC, Yang A, Mazzaferro S, Mali I, Cahn O, Kentistou K, Rowley C, Stewart N, Seah JWE, Pisupati V , Kirwan P et al (2023) , Cold Spring Harbor Laboratory.
Bin JM, Suminaite D, Benito-Kwiecinski SK, Kegel L, Rubio-Brotons M, Early JJ, Soong D, Livesey MR, Poole RJ & Lyons DA (2023) , Cold Spring Harbor Laboratory.
Madden ME, Suminaite D, Ortiz E, Early JJ, Koudelka S, Livesey MR, Bianco IH, Granato M & Lyons DA () , Cold Spring Harbor Laboratory.
Castelli LM, Cutillo L, Souza CDS, Sanchez-Martinez A, Granata I, Myszczynska MA, Heath PR, Livesey MR, Ning K, Azzouz M , Shaw PJ et al () , Cold Spring Harbor Laboratory.
Kegel L, Marshall-Phelps KLH, Baraban M, Almeida RG, Rubio-Brotons M, Klingseisen A, Benito-Kwiecinski S, Early JJ, Bin J, Livesey MR , Poole RJ et al () , Cold Spring Harbor Laboratory.

Research group

Ms Iris Pasniceanu (PhD student)
Mr Manpreet Atwal (PhD student)
Ms Marilina Douloudi (PhD Student)

Research Lab Alumni (including current position where known)
Ms Niamh Conway (MSc student)
Ms Zahra Shather (MSc student, Research assistant at Samsara Therapeutics)
Ms Ergita Bali (Technician, PhD student at University of ��߲ݴ�ý)
Ms Amelia Potter (MSc student)

Grants

The lab is currently funded by the following sources;

Motor Neurone Disease Association
MRC
Industrial collaboration with MSD

Previous funders

ARUK
Royal Society
Rosetrees Trust

Professional activities and memberships

Internal:

Post-graduate research tutor
MSc teaching

External:

Peer reviewer for journals including Nature Communications, Cell Reports, Journal of Neuroscience and Journal of Physiology.
Peer reviewer for grant funding bodies including MRC, BBSRC, NC3Rs, MNDA and ARUK.

���߲ݴ�ý

School of Medicine and Population Health