Dr Andrew Grierson

PhD

Neuroscience, School of Medicine and Population Health

Senior Lecturer in Neuroscience

a.j.grierson@sheffield.ac.uk
+44 114 222 2277

Full contact details

Dr Andrew Grierson
Neuroscience, School of Medicine and Population Health
Room B25
含羞草传媒 Institute for Translational Neuroscience (SITraN)
385a Glossop Road
含羞草传媒
S10 2HQ
Qualifications

2009 鈥損resent: Senior Lecturer
2001 - 2008: Lecturer, University of 含羞草传媒
1997 - 2001: Postdoctoral Research Associate, Institute of Psychiatry, Kings College London
1994 - 1997: Postdoctoral Research Associate, University of Amsterdam, Netherlands
1991 - 1994: PhD (Molecular Genetics) University of 含羞草传媒
1988 - 1991: BSc (Genetics) University of 含羞草传媒

Research interests

Research in my laboratory concerns identifying the molecular mechanisms underlying the regulation of axonal transport in health and disease. In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP).

In addition we are developing and characterising novel vertebrate models of neurodegeneration in zebrafish and mouse. With support from the NC3Rs we are refining the widely used SOD1G93A model of motor neuron disease.

Current projects

  • Preclinical testing of HDAC6 inhibition in a zebrafish model of CMT2A (Hereditary Neuropathy Foundation)Investigating the function of the C9ORF72 protein in motor neuron disease (University Studentship)

  • Preclinical assessment of histone deacetylase 6 (HDAC6) inhibition as a therapy for hereditary spastic paraplegia (Spastic Paraplegia Foundation)

  • ANIMPACT: An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation (European Union) Zebrafish C9orf72 loss of function models of ALS (MND Association)

  • Role of C9ORF72 in proteostasis. (De Vos PI) (Thierry Latran Foundation) ROLE OF MITOCHONDRIA IN C9ORF72-RELATED ALS/MND (De Vos is PI) (MND Association)

  • Preclinical assessment of spastin gene replacement therapy as a treatment for hereditary spastic paraplegia (Spastic Paraplegia Foundation)

Research collaborations

  • Pamela Shaw, Academic Neurology Unit, University of 含羞草传媒
  • , University of 含羞草传媒
Publications

Journal articles

  • Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-脕lvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) . Frontiers in Cellular Neuroscience, 16. RIS download Bibtex download
  • Marchi PM, Marrone L, Brasseur L, Coens A, Webster CP, Bousset L, Destro M, Smith EF, Walther CG, Alfred V , Marroccella R et al (2022) . Life Science Alliance, 5(9), e202101276-e202101276. RIS download Bibtex download
  • Bauer CS, Webster CP, Shaw AC, Kok JR, Castelli LM, Lin Y-H, Smith EF, Illanes-脕lvarez F, Higginbottom A, Shaw PJ , Azzouz M et al (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in cellular neuroscience, 16. RIS download Bibtex download
  • Derrick CJ, Pollitt EJG, Sevilla Uruchurtu AS, Hussein F, Grierson AJ & No毛l ES (2021) . Development. RIS download Bibtex download
  • Keerie A, Brown-Wright H, Kirkland I, Grierson A, Alix JJP, Holscher C & Mead RJ (2021) . Scientific Reports, 11. RIS download Bibtex download
  • Ciervo Y, Gatto N, Allen C, Grierson A, Ferraiuolo L, Mead RJ & Shaw PJ (2021) . Molecular Therapy 鈥 Methods & Clinical Development, 21, 413-433. RIS download Bibtex download
  • Gibson JF, Prajsnar TK, Hill CJ, Tooke AK, Serba JJ, Tonge RD, Foster SJ, Grierson AJ, Ingham PW, Renshaw SA & Johnston SA (2020) . Autophagy. RIS download Bibtex download
  • Fernandes JG, Franco NH, Grierson AJ, Hultgren J, Furley AJW & Olsson IAS (2019) . BMJ Open Science, 3(1). RIS download Bibtex download
  • Webster CP, Smith EF, Grierson AJ & De Vos K (2016) . Small GTPases. RIS download Bibtex download
  • Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ , Kaspar BK et al (2016) . EMBO Journal, 35(15), 1656-1676. RIS download Bibtex download
  • Lukashchuk V, Lewis KE, Coldicott I, Grierson AJ & Azzouz M (2016) . Molecular Therapy - Methods and Clinical Development, 3. RIS download Bibtex download
  • Allen SP, Duffy LM, Shaw PJ & Grierson AJ (2015) . Neurobiology of Aging, 36(10), 2893-2903. RIS download Bibtex download
  • Bennett EJ, Mead RJ, Azzouz M, Shaw PJ & Grierson AJ (2014) . PLoS ONE, 9(9), e107918-e107918. RIS download Bibtex download
  • Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T & Prescott TJ (2014) . Behav Brain Res, 259, 274-283. RIS download Bibtex download
  • Allen SP, Rajan S, Duffy L, Mortiboys H, Higginbottom A, Grierson AJ & Shaw PJ (2014) . Neurobiol Aging, 35(6), 1499-1509. RIS download Bibtex download
  • Richardson K, Allen SP, Mortiboys HJ, Grierson AJ, Wharton SB, Ince PG, Shaw PJ & Heath PR (2013) . Plos One, 6(8), e68256-e68256. RIS download Bibtex download
  • Mead RJ, Higginbottom A, Allen SP, Kirby J, Bennett E, Barber SC, Heath PR, Coluccia A, Patel N, Gardner I , Brancale A et al (2013) . Free Radic Biol Med, 61, 438-452. RIS download Bibtex download
  • Hewamadduma CAA, Grierson AJ, Ma TP, Pan L, Moens CB, Ingham PW, Ramesh T & Shaw PJ (2013) . Hum Mol Genet, 22(12), 2376-2386. RIS download Bibtex download
  • Chapman AL, Bennett EJ, Ramesh TM, De Vos KJ & Grierson AJ (2013) . PLoS One, 8(6), e67276. RIS download Bibtex download
  • Hameed A, Bennett E, Ciani B, Hoebers LPC, Milner R, Lawrie A, Francis SE & Grierson AJ (2013) . PLoS One, 8(1), e54636. RIS download Bibtex download
  • Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ (2012) . PLoS ONE, 7(7). RIS download Bibtex download
  • Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M & Shaw PJ (2011) . Nat Rev Neurol, 7(11), 616-630. RIS download Bibtex download
  • Mead RJ, Bennett EJ, Kennerley AJ, Sharp P, Sunyach C, Kasher P, Berwick J, Pettmann B, Battaglia G, Azzouz M , Grierson A et al (2011) . PLoS One, 6(8), e23244. RIS download Bibtex download
  • Duffy LM, Chapman AL, Shaw PJ & Grierson AJ (2011) . Neuropathol Appl Neurobiol, 37(4), 336-352. RIS download Bibtex download
  • Kasher PR, Namavar Y, van Tijn P, Fluiter K, Sizarov A, Kamermans M, Grierson AJ, Zivkovic D & Baas F (2011) . Hum Mol Genet, 20(8), 1574-1584. RIS download Bibtex download
  • Mahmood QA, Whitworth A & Grierson A (2010) Role of Mitochondrial Dynamics in Neurodegeneration. J NEUROGENET, 24, 64-65. RIS download Bibtex download
  • Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) . Sci Transl Med, 2(35), 35ra42. RIS download Bibtex download
  • Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE , Morrison KE et al (2010) . PLoS One, 5(3), e9872. RIS download Bibtex download
  • Hewamadduma C, McDermott C, Kirby J, Grierson A, Panayi M, Dalton A, Rajabally Y & Shaw P (2009) . Neurogenetics, 10(2), 105-110. RIS download Bibtex download
  • Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CCJ , Shaw PJ et al (2009) . J Neurochem, 110(1), 34-44. RIS download Bibtex download
  • Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A & Nasir J (2008) . Eur J Neurosci, 27(7), 1626-1633. RIS download Bibtex download
  • De Vos KJ, Grierson AJ, Ackerley S & Miller CCJ (2008) . Annu Rev Neurosci, 31, 151-173. RIS download Bibtex download
  • De Vos KJ, Chapman AL, Tennant ME, Manser C, Tudor EL, Lau K-F, Brownlees J, Ackerley S, Shaw PJ, McLoughlin DM , Shaw CE et al (2007) . Hum Mol Genet, 16(22), 2720-2728. RIS download Bibtex download
  • Sathasivam S, Grierson AJ & Shaw PJ (2005) . Neuropathol Appl Neurobiol, 31(5), 467-485. RIS download Bibtex download
  • Connell JW, Rodriguez-Martin T, Gibb GM, Kahn NM, Grierson AJ, Hanger DP, Revesz T, Lantos PL, Anderton BH & Gallo J-M (2005) . Brain Res Mol Brain Res, 137(1-2), 104-109. RIS download Bibtex download
  • De Vos KJ, Allan VJ, Grierson AJ & Sheetz MP (2005) . Curr Biol, 15(7), 678-683. RIS download Bibtex download
  • Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS , Anderton BH et al (2004) . Mol Cell Neurosci, 26(2), 354-364. RIS download Bibtex download
  • Saha AR, Hill J, Utton MA, Asuni AA, Ackerley S, Grierson AJ, Miller CC, Davies AM, Buchman VL, Anderton BH & Hanger DP (2004) . J Cell Sci, 117(Pt 7), 1017-1024. RIS download Bibtex download
  • McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KMD & Shaw PJ (2003) . Ann Neurol, 54(6), 748-759. RIS download Bibtex download
  • Wharton SB, McDermott CJ, Grierson AJ, Wood JD, Gelsthorpe C, Ince PG & Shaw PJ (2003) . J Neuropathol Exp Neurol, 62(11), 1166-1177. RIS download Bibtex download
  • Ackerley S, Thornhill P, Grierson AJ, Brownlees J, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2003) . J Cell Biol, 161(3), 489-495. RIS download Bibtex download
  • Grierson AJ & Shaw PJ (2003) . Blue Books of Practical Neurology, 28(C), 237-257. RIS download Bibtex download
  • Brownlees J, Ackerley S, Grierson AJ, Jacobsen NJO, Shea K, Anderton BH, Leigh PN, Shaw CE & Miller CCJ (2002) . Hum Mol Genet, 11(23), 2837-2844. RIS download Bibtex download
  • Menzies FM, Grierson AJ, Cookson MR, Heath PR, Tomkins J, Figlewicz DA, Ince PG & Shaw PJ (2002) . J Neurochem, 82(5), 1118-1128. RIS download Bibtex download
  • Gibb G, Hanger D, Anderton B, Connell J, Grierson A, De Silva R & Revesz T (2002) Comparision of tau protein expression in AD, FTDP-17, PSP and Pick's disease. NEUROBIOL AGING, 23(1), S505-S505. RIS download Bibtex download
  • Miller CCJ, Ackerley S, Brownlees J, Grierson AJ, Jacobsen NJO & Thornhill P (2002) . Cell Mol Life Sci, 59(2), 323-330. RIS download Bibtex download
  • Grierson AJ, Shaw CE & Miller CC (2001) . Biochim Biophys Acta, 1536(1), 13-20. RIS download Bibtex download
  • Grierson AJ, Johnson GV & Miller CC (2001) . Neurosci Lett, 298(1), 9-12. RIS download Bibtex download
  • Standen CL, Brownlees J, Grierson AJ, Kesavapany S, Lau KF, McLoughlin DM & Miller CC (2001) . J Neurochem, 76(1), 316-320. RIS download Bibtex download
  • Ackerley S, Grierson AJ, Brownlees J, Thornhill P, Anderton BH, Leigh PN, Shaw CE & Miller CC (2000) . J Cell Biol, 150(1), 165-176. RIS download Bibtex download
  • Utton MA, Killick R, Grierson A, Ackerly S, Lovestone S & Miller C (2000) . Neurobiology of Aging, 21, 113-113. RIS download Bibtex download
  • Grierson AJ, Mootoosamy RC & Miller CC (1999) . Neurosci Lett, 277(1), 9-12. RIS download Bibtex download
  • Grierson AJ (1999) Corrigendum: An integrated map of chromosome 18 CAG trinucleotide repeat loci (European Journal of Human Genetics (1999) 7 (12-19)). European Journal of Human Genetics, 7(8), 944. RIS download Bibtex download
  • Grierson AJ, van Groenigen M, Groot NP, Lindblad K, Hoovers JM, Schalling M, de Belleroche J & Baas F (1999) . Eur J Hum Genet, 7(1), 12-19. RIS download Bibtex download
  • Meijerink PH, Yanakiev P, Zorn I, Grierson AJ, Bikker H, Dye D, Kalaydjieva L & Baas F (1998) . Eur J Biochem, 254(2), 297-303. RIS download Bibtex download
  • Guidato S, McLoughlin DM, Grierson AJ & Miller CC (1998) . J Neurochem, 70(1), 335-340. RIS download Bibtex download
  • Grierson AJ, Hodgkins MA, Hancock BW, Goepel JR, Royds J & Goyns MH (1996) . Leuk Lymphoma, 23(3-4), 353-363. RIS download Bibtex download
  • Lorigan PC, Grierson AJ, Goepel JR, Coleman RE & Goyns MH (1996) . Cancer Lett, 104(1), 27-30. RIS download Bibtex download
  • Grierson A, van Groenigen M & Baas F (1996) . Psychiatric Genetics, 6(3), 148-148. RIS download Bibtex download
  • Grierson AJ, Hammond DW, Goepel JR, Hancock BW & Goyns MH (1994) . Ann Oncol, 5 Suppl 1, 47-50. RIS download Bibtex download
  • Bauer CS, Cohen RN, Sironi F, Livesey MR, Gillingwater TH, Highley JR, Fillingham DJ, Coldicott I, Smith EF, Gibson YB , Webster CP et al () . Acta Neuropathologica. RIS download Bibtex download
  • 艁ysyganicz PK, Pooranachandran N, Liu X, Adamson KI, Zielonka K, Elworthy S, van Eeden FJ, Grierson AJ & Malicki JJ () . Frontiers in Cell and Developmental Biology, 9. RIS download Bibtex download
  • Rocca RA, Magoon G, Reynolds DF, Krahn T, Tilroe VO, Op den Velde Boots PM & Grierson AJ () . PLoS ONE, 7(8). RIS download Bibtex download
  • Grierson A, Sardinia F, Pisciottani A, Ferrara M, Valente D, Casella M, Crescenzi M, Peschiaroli A, Casali C, Soddu S & Rinaldo C () Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation. Life Science Alliance. RIS download Bibtex download

Chapters

  • Miller CCJ, Ackerley S, Brownlees J, Grierson AJ & Thornhill P () , Neuroinflammation (pp. 089-097). Humana Press RIS download Bibtex download

Conference proceedings papers

  • Mohammedeid A, Bhargava A, Godena VK, Kong S, Tennore R, Grierson AJ, Xu J, Shaw PJ, Azzouz M & Ning K (2019) Arfaptin-2 as a therapeutic target for amyotrophic lateral sclerosis (ALS). HUMAN GENE THERAPY, Vol. 30(8) (pp A19-A20) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Higginbottom A & Shaw P (2015) . Journal of the Neurological Sciences, Vol. 357 (pp e49-e49) RIS download Bibtex download
  • Adamson KI & Grierson AJ (2015) FISH ON DRUGS: A ZEBRAFISH PRECLINICAL MODEL FOR CMT2A. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 92-93) RIS download Bibtex download
  • Mohammedeid A, Ning K, Kong SC, Azzouz M & Grierson A (2014) Regulation of protein aggregation by Arfaptin2 in amyotrophic lateral sclerosis. HUMAN GENE THERAPY, Vol. 25(5) (pp A14-A14) RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78 RIS download Bibtex download
  • Hewamadduma C, Grierson A, Moens C, Pan L, Ma T, Ingham P, Ramesh T & Shaw P (2012) A novel alternative splicing event rescues the mutant tardbp phenotype in a zebrafish model of TDP-43 related Amyotrophic Lateral Sclerosis (ALS). NEUROLOGY, Vol. 78 RIS download Bibtex download
  • Hewamadduma C, Higgenbottom CAA, Moens C, Helde K, Raman R, Tennore R, Grierson A & Shaw PJ (2012) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 83(3) RIS download Bibtex download
  • Eckmann J, Eckert SH, Leuner K, Bordet T, Pruss R, Grierson A, Shaw P, Clemens L, Nguyen HP, Mueller WE & Eckert GP (2011) Impact of Olesoxime on disease related mitochondrial membrane properties in mouse models of neurodegenerative diseases. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Vol. 383 (pp 51-51) RIS download Bibtex download
  • Valori CF, Ning K, Wyles M, Mead RJ, Grierson AJ, Shaw PJ & Azzouz M (2010) Systemic delivery of scAAV9 expressing SMN prolongs survival in a mouse model of SMA. HUMAN GENE THERAPY, Vol. 21(10) (pp 1424-1425) RIS download Bibtex download
  • Clemens LE, Grierson A, De Vos K, Riess O & Nguyen HP (2010) . JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 81 (pp A5-A5) RIS download Bibtex download
  • Sathasivam S, Grierson AJ & Shaw PJ (2005) Alterations of the Bcl-2 family oncoprotein members in a cell culture model of familial SOD1-related motor neurone disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 76(1) (pp 157-157) RIS download Bibtex download
  • McDermott CJ, Grierson A, Wood J & Shaw PJ (2003) Hereditary spastic paraparesis associated with mutation in spastin (SPG4): A disorder of axonal transport?. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 74(10) (pp 1453-1453) RIS download Bibtex download

Preprints

  • Butler L, Adamson KI, Johnson SL, Jestice LH, Price CJ, Stavish D, Pooranachandran N, Malicki JJ, Tsakiridis A, Grierson AJ & Barbaric I () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Marchi PM, Marrone L, Brasseur L, Bousset L, Webster CP, Destro M, Smith EF, Walther CG, Alfred V, Marroccella R , Robinson D et al () , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Magoon GR, Banks RH, Rottensteiner C, Schrack BE, Tilroe VO, Robb T & Grierson AJ () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group
  • Natalie Rounding (PhD student)
  • Khlood Mehdar (PhD student)
  • Gary Shaw (Research Technician)
  • Katie Adamson (Research Technician)
  • Yolanda Gibson (PhD student)
Grants