Dr Steven Reynolds

Clinical Medicine, School of Medicine and Population Health

Preclinical MRI Facility Manager

Dr Steven Reynolds
Profile picture of Dr Steven Reynolds
Steven.Reynolds@sheffield.ac.uk
+44 114 215 9596

Full contact details

Dr Steven Reynolds
Clinical Medicine, School of Medicine and Population Health
C Floor
Royal Hallamshire Hospital
Glossop Road
含羞草传媒
S10 2JF
Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

In 2009, I joined the University of 含羞草传媒 as a Senior Research fellow on a CRUK funded programme grant. Here I set up the lab to study cancer metabolism by Hyperpolarised Magnetic Resonance Imaging and Spectroscopy (MRI/S). Previously, I held positions in industry both as part of GE Healthcare (2001-2006), developing scientific instruments, and Oxford Instruments (2006 鈥 2009), where I led the MRS facility and was responsible for project delivery using the HyperSense hyperpolarisation instrument. It was from these roles that I developed an interest in hyperpolarised magnetic resonance experiments and metabolism.

I have a degree in chemistry from Aston University, where I also received my PhD. I have held research positions at the University of Surrey and the University of Cambridge. 

Research interests

My main research interest is in the use of (MRS) to study cellular metabolism and metabolomics. This is augmented by the use of hyperpolarisation technology that allows in vivo and in vitro cellular metabolism to be studied in real time.

The studies the metabolism of these unique cells to learn more about male factor infertility.  Sperm undergo a lot of changes before fertilising an egg. These changes require energy and our research examines how sperm metabolise at different stages of their journey through the female reproductive tract. We use MRS to track the conversion of substrates by different metabolic pathways to understand how sperm produce this energy. Alongside this, I have a longstanding collaboration with Prof Dilly Anumba in studying the metabolic triggers of preterm birth. We examine how the bacteria present in the vagina can influence pregnancy outcomes. These bacteria produce metabolites that can be quantified by MRS and could be used to predict the likelihood of preterm birth.

I also manage the 7T and 9.4T magnetic resonance spectroscopy and imaging facility at the University of 含羞草传媒. Here I have a number of collaborations to develop the use of high resolution MRI, including live zebrafish imaging.

Publications

Show: Featured publications All publications

Journal articles

  • Amabebe E, Reynolds S, He X, Wood R, Stern V & Anumba DOC (2019) . PLOS ONE, 14(9), 222455-222455. RIS download Bibtex download
  • Calvert SJ, Reynolds S, Paley MN, Walters SJ & Pacey AA (2019) . Molecular Human Reproduction, 25(1), 30-41. RIS download Bibtex download
  • Reynolds S, Metcalf S, Cochrane EJ, Collins RC, Jones S, Paley MNJ & Tozer GM (2017) . Magnetic Resonance in Medicine, 78(6), 2116-2126. RIS download Bibtex download
  • Reynolds S, Calvert SJ, Paley MN & Pacey AA (2017) . Molecular Human Reproduction, 23(7), 441-451. RIS download Bibtex download
  • Reynolds S, Ismail N, Calvert S, Pacey A & Paley M (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba DOC (2016) . Frontiers in Medicine, 3. RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern VL, Parker JL, Stafford GP, Paley MN & Anumba DOC (2016) . Metabolomics, 12(4), 67-67. RIS download Bibtex download
  • Bluff JE, Reynolds S, Metcalf S, Alizadeh T, Kazan SM, Bucur A, Wholey EG, Bibby BAS, Williams L, Paley MN & Tozer GM (2015) . Radiotherapy and Oncology, 116(3), 392-399. RIS download Bibtex download
  • Kailavasan M, Rehman I, Reynolds S, Bucur A, Tozer G & Paley M (2014) . NMR Biomed, 27(5), 610-616. RIS download Bibtex download
  • Reynolds S, Bucur A, Port M, Alizadeh T, Kazan SM, Tozer GM & Paley MNJ (2014) . J Magn Reson, 239, 1-8. RIS download Bibtex download
  • Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN & Tozer GM (2013) . Magn Reson Med, 70(4), 943-953. RIS download Bibtex download
  • Jamin Y, Gabellieri C, Smyth L, Reynolds S, Robinson SP, Springer CJ, Leach MO, Payne GS & Eykyn TR (2009) . Magnetic Resonance in Medicine, 62(5), 1300-1304. RIS download Bibtex download
  • Reynolds S & Patel H (2008) . Applied Magnetic Resonance, 34(3-4), 495-508. RIS download Bibtex download
  • Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO & Eykyn TR (2008) . Journal of the American Chemical Society, 130(14), 4598-4599. RIS download Bibtex download
  • Paley M, Reynolds S, Ismail N, Herigstad M, Jarvis D & Griffiths P () . Technologies, 5(1), 6-6. RIS download Bibtex download

All publications

Journal articles

  • Hern谩ndez-Quiles M, Martinez Campesino L, Morris I, Ilyas Z, Reynolds S, Soon Tan N, Sobrevals Alcaraz P, Stigter ECA, Varga 脕, Varga J , van Es R et al (2023) . Molecular Metabolism, 78. RIS download Bibtex download
  • Amabebe E, Bhatnagar N, Kamble N, Reynolds S & Anumba DO (2022) . Reproduction and Fertility, 3(3), L6-L8. RIS download Bibtex download
  • Reynolds S, Calvert SJ, Walters SJ, Paley MN & Pacey A (2022) . Reproduction and Fertility. RIS download Bibtex download
  • Amabebe E, Reynolds S & Anumba DOC (2021) . Reproduction and Fertility, 2(4), L4-L6. RIS download Bibtex download
  • Amabebe E, Reynolds S, He X, Wood R, Stern V & Anumba DOC (2019) . PLOS ONE, 14(9), 222455-222455. RIS download Bibtex download
  • Calvert SJ, Reynolds S, Paley MN, Walters SJ & Pacey AA (2019) . Molecular Human Reproduction, 25(1), 30-41. RIS download Bibtex download
  • Reynolds S, Metcalf S, Cochrane EJ, Collins RC, Jones S, Paley MNJ & Tozer GM (2017) . Magnetic Resonance in Medicine, 78(6), 2116-2126. RIS download Bibtex download
  • Stafford GP, Parker JL, Amabebe E, Kistler J, Reynolds S, Stern V, Paley M & Anumba DOC (2017) . Frontiers in Physiology, 8. RIS download Bibtex download
  • Reynolds S, Calvert SJ, Paley MN & Pacey AA (2017) . Molecular Human Reproduction, 23(7), 441-451. RIS download Bibtex download
  • Reynolds S, Ismail N, Calvert S, Pacey A & Paley M (2017) . Scientific Reports, 7. RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba DOC (2016) . Frontiers in Medicine, 3. RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern VL, Parker JL, Stafford GP, Paley MN & Anumba DOC (2016) . Metabolomics, 12(4), 67-67. RIS download Bibtex download
  • Bluff JE, Reynolds S, Metcalf S, Alizadeh T, Kazan SM, Bucur A, Wholey EG, Bibby BAS, Williams L, Paley MN & Tozer GM (2015) . Radiotherapy and Oncology, 116(3), 392-399. RIS download Bibtex download
  • Kailavasan M, Rehman I, Reynolds S, Bucur A, Tozer G & Paley M (2014) . NMR Biomed, 27(5), 610-616. RIS download Bibtex download
  • Reynolds S, Bucur A, Port M, Alizadeh T, Kazan SM, Tozer GM & Paley MNJ (2014) . J Magn Reson, 239, 1-8. RIS download Bibtex download
  • Kazan SM, Reynolds S, Kennerley A, Wholey E, Bluff JE, Berwick J, Cunningham VJ, Paley MN & Tozer GM (2013) . Magn Reson Med, 70(4), 943-953. RIS download Bibtex download
  • Reynolds S, Kazan SM, Bluff JE, Port M, Wholey E, Tozer GM & Paley M (2012) Fully MR-Compatible Syringe Pump for the Controllable Injection of Hyperpolarized Substrate in Animals. Applied Magnetic Resonance, 1-11. RIS download Bibtex download
  • Jamin Y, Gabellieri C, Smyth L, Reynolds S, Robinson SP, Springer CJ, Leach MO, Payne GS & Eykyn TR (2009) . Magnetic Resonance in Medicine, 62(5), 1300-1304. RIS download Bibtex download
  • Reynolds S & Patel H (2008) . Applied Magnetic Resonance, 34(3-4), 495-508. RIS download Bibtex download
  • Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO & Eykyn TR (2008) . Journal of the American Chemical Society, 130(14), 4598-4599. RIS download Bibtex download
  • Fries M, Stott KM, Reynolds S & Perham RN (2007) . Journal of Molecular Biology, 366(1), 132-139. RIS download Bibtex download
  • Hamilton N, Allen C & Reynolds S () . NMR in Biomedicine. RIS download Bibtex download
  • Marrone L, Marchi PM, Webster CP, Marroccella R, Coldicott I, Reynolds S, Alves-Cruzeiro J, Yang Z-L, Higginbottom A, Khundadze M , Shaw PJ et al () . Human Molecular Genetics. RIS download Bibtex download
  • Herigstad M, Granados-Aparici S, Pacey A, Paley M & Reynolds S () . RIS download Bibtex download
  • Paley M, Reynolds S, Ismail N, Herigstad M, Jarvis D & Griffiths P () . Technologies, 5(1), 6-6. RIS download Bibtex download
  • Amabebe E, Anumba DO & Reynolds S () . RIS download Bibtex download
  • Reynolds S, Kazan SM, Anton A, Alizadeh T, Gunn RN, Paley MN, Tozer GM & Cunningham VJ () . NMR in Biomedicine. RIS download Bibtex download

Chapters

  • Paley M, Kaka S, Hilliard H, Zaytsev A, Bucur A, Reynolds S, Liu W, Milne E & Cook G (2015) In Hassanien A & Azar A (Ed.), Brain-Computer Interfaces (pp. 185-213). RIS download Bibtex download

Conference proceedings papers

  • Amabebe E, Chaudhuri R, Reynolds S & Anumba DOC (2023) Metabolic Characteristics of Vaginal Dysbiosis Associated Bacteria: Mobiluncus curtisii and Lactobacillus iners. REPRODUCTIVE SCIENCES, Vol. 30 (pp 192A-192A) RIS download Bibtex download
  • May GR, Amabebe E, Anumba DO & Reynolds S (2021) Metabolic Profiling of Gardenerella vaginalis: A Vaginal Dysbiosis and Preterm Birth-Associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 215A-216A) RIS download Bibtex download
  • Amabebe E, Anumba D & Reynolds S (2021) Differential Vaginal Lactobacillus Species Metabolism of Glucose, L- and D-lactate by(13)C-Nuclear Magnetic Resonance Spectroscopy.. REPRODUCTIVE SCIENCES, Vol. 28(SUPPL 1) (pp 216A-216A) RIS download Bibtex download
  • Amabebe E, Anumba D & Reynolds S (2020) Differential Metabolic Profiles of Lactobacillus Species and Preterm Birth-associated Bacteria.. REPRODUCTIVE SCIENCES, Vol. 27(SUPPL 1) (pp 122A-122A) RIS download Bibtex download
  • Amabebe E, Reynolds S & Anumba DO (2019) Discriminative Capacity of H-1-MRS Spectrum Binning for Preterm Delivery-Associated Lactobacilli-Dominated Vaginal Microbiota.. REPRODUCTIVE SCIENCES, Vol. 26 (pp 212A-212A) RIS download Bibtex download
  • Amabebe E, Reynolds S, Stern V, Stafford G, Paley M & Anumba D (2017) Decreased cervicovaginal fluid glutamate improves the predictive value of acetate for risk of preterm delivery within two weeks of presentation with threatened preterm labour. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol. 124 (pp 127-127) RIS download Bibtex download
  • Parker J, Stafford GP, Stern V, Amabebe E, Reynolds S, Paley M & Anumba DOC (2016) Prognostic Microbiomial and Metabolite Markers of Preterm Birth in Second Trimester Cervicovaginal Fluid from Women at Risk.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 128A-128A) RIS download Bibtex download
  • Stern V, Amabebe E, Reynolds S, Stafford G, Paley M & Anumba D (2016) The Association of Cervicovaginal Fluid Metabolites at 20-22 Weeks Gestation with Quantitative Fetal Fibronectin, Ultrasound Cervical Length and Gestational Age at Delivery in Asymptomatic Pregnant Women.. REPRODUCTIVE SCIENCES, Vol. 23 (pp 190A-191A) RIS download Bibtex download
  • Amabebe E, Stern V, Parker J, Reynolds S, Stafford G, Paley M & Anumba D (2015) Elucidating Potential Metabolite Markers of Preterm Birth in Cervicovaginal Secretions By Nuclear Magnetic Resonance Spectroscopy. REPRODUCTIVE SCIENCES, Vol. 22 (pp 130A-130A) RIS download Bibtex download

Preprints

  • Hamilton N, Allen C & Reynolds S () , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group

PhD students

  • Evie Gruszyk
Teaching interests

I deliver the MRI component of the FRCR (Radiology) programme to the Medical school Undergraduate course. I also contribute to the Student Selected Components on Phase 1b (Research Methods). I supervise Master students on the Reproductive and Developmental medicine course. Outside of the Medical school I provide research experiences for the University鈥檚 SURE scheme and .

Professional activities and memberships
  • Member of the Royal Society of Chemistry.
  • Member of the Institute for Physics.