Professor Claire Lewis

Clinical Medicine, School of Medicine and Population Health

Professor of Molecular & Cellular Pathology

claire.lewis@sheffield.ac.uk
+44 114 215 9012

Full contact details

Professor Claire Lewis
Clinical Medicine, School of Medicine and Population Health
Floor E
The Medical School
Beech Hill Road
º¬Ð߲ݴ«Ã½
S10 2RX
Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

After completing my DPhil (PhD) in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, I held two postdoctoral positions and a Lectureship in the Medical School there before moving to join the Medical School in º¬Ð߲ݴ«Ã½ in 1996.  I currently hold a Personal Chair in Molecular & Cellular Pathology and head a team of pre and postdoctoral scientists.

I was awarded a DSc by Oxford University in 2006 for my contribution to the field of tumour inflammation research.  During my career, my group has filed numerous patent applications and worked with various collaborators in the commercial sector.  I also enjoyed running a spin-out company and was delighted to receive Cancer Research Horizon's Woman Entrepreneur Award in 2022.

Research interests

Our research is focused mainly on the role of inflammatory cells called macrophages in tumour progression and responses to conventional anti-cancer treatments like chemotherapy and irradiation.

We have also developed ways of using these cells to target therapeutic genes and viruses to tumours. Our work was reported in the national press (,) and is mainly funded by grants from Breast Cancer Now, Prostate Cancer UK, The European Union, Cancer Research UK and Team Verrico.

Publications

Show: Featured publications All publications

Journal articles

  • Coulton A, Murai J, Qian D, Thakkar K, Lewis CE & Litchfield K (2024) . Nature Communications, 15. RIS download Bibtex download
  • Moamin MR, Allen R, Woods SL, Brown JE, Nunns H, Juncker-Jensen A & Lewis CE (2023) . Frontiers in Immunology, 14. RIS download Bibtex download
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) . Future Pharmacology, 2(4), 444-459. RIS download Bibtex download
  • Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Janabi HA, Demiral S, Perrie Y, Essand M, Weglarz A , Cruz LJ et al (2022) . Nanomedicine: Nanotechnology, Biology and Medicine, 40. RIS download Bibtex download
  • Al-Janabi H & Lewis CE (2021) . Cancer Research, 81(21), 5399-5400. RIS download Bibtex download
  • Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) . Biomaterials, 198, 180-193. RIS download Bibtex download
  • Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2019) . Nature Cell Biology, 21(2), 190-202. RIS download Bibtex download
  • Yang M, McKay D, Pollard JW & Lewis CE (2018) . Cancer Research, 78(19), 5492-5503. RIS download Bibtex download

All publications

Books

  • Staton C, Lewis CE & Bicknell R (2007) Angiogenesis Assays: A Critical Appraisal of Current Techniques. Wiley-Blackwell. RIS download Bibtex download

Journal articles

  • Al-janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, Rescigno P, de Bono J, Nunns H, Bailey C , Junker-Jensen A et al (2024) . Journal for ImmunoTherapy of Cancer, 12(7), e009368-e009368. RIS download Bibtex download
  • Coulton A, Murai J, Qian D, Thakkar K, Lewis CE & Litchfield K (2024) . Nature Communications, 15. RIS download Bibtex download
  • Moamin MR, Allen R, Woods SL, Brown JE, Nunns H, Juncker-Jensen A & Lewis CE (2023) . Frontiers in Immunology, 14. RIS download Bibtex download
  • Kwan A, Howard F, Winder N, Atkinson E, Jailani A, Patel PB, Allen R, Ottewell PD, Shaw GC, Conner J , Wilson C et al (2022) . Future Pharmacology, 2(4), 444-459. RIS download Bibtex download
  • Iscaro A, Jones C, Forbes N, Mughal A, Howard FN, Janabi HA, Demiral S, Perrie Y, Essand M, Weglarz A , Cruz LJ et al (2022) . Nanomedicine: Nanotechnology, Biology and Medicine, 40. RIS download Bibtex download
  • Juncker-Jensen A, Stavrou N, Moamin M, Nagy M, Allen R, Cox A & Lewis C (2021) . Journal for ImmunoTherapy of Cancer, 9(Suppl 2), A867-A867. RIS download Bibtex download
  • Al-Janabi H & Lewis CE (2021) . Cancer Research, 81(21), 5399-5400. RIS download Bibtex download
  • Greene C, O'Doherty E, Abdullahi Sidi F, Bingham V, Fisher NC, Humphries MP, Craig SG, Harewood L, McQuaid S, Lewis C & James J (2021) . Biopreservation and Biobanking, 19(4), 324-331. RIS download Bibtex download
  • Kwan A, Winder NJ, Atkinson E, Al-Janabi HH, Allen RJ, Hughes R, Moamin MR, Louie R, Evans D, Hutchinson M , Capper DT et al (2020) . Mol Cancer Ther. RIS download Bibtex download
  • Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al (2019) . Oncogene, 38(28), 5670-5685. RIS download Bibtex download
  • Boussommier-Calleja A, Atiyas Y, Haase K, Headley M, Lewis C & Kamm RD (2019) . Biomaterials, 198, 180-193. RIS download Bibtex download
  • Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C , Cassará A et al (2019) . Nature Cell Biology, 21(2), 190-202. RIS download Bibtex download
  • Yang M, McKay D, Pollard JW & Lewis CE (2018) . Cancer Research, 78(19), 5492-5503. RIS download Bibtex download
  • Lapenna A, De Palma M & Lewis CE (2018) . Nature Reviews Immunology, 18(11), 689-702. RIS download Bibtex download
  • Lewis CE, Harney AS & Pollard JW (2016) . Cancer Cell, 30(1), 18-25. RIS download Bibtex download
  • Hughes R, Qian B-Z, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M , Gonzalez-Angulo AM et al (2015) . Cancer Research, 75(17), 3479-3491. RIS download Bibtex download
  • Muthana M, Kennerley AJ, Hughes R, Fagnano E, Richardson J, Paul M, Murdoch C, Wright F, Payne C, Lythgoe MF , Farrow N et al (2015) . Nature Communications, 6. RIS download Bibtex download
  • Galluzzi L, Vacchelli E, Bravo-San Pedro J-M, Buque A, Senovilla L, Baracco EE, Bloy N, Castoldi F, Abastado J-P, Agostinis P , Apte RN et al (2014) . Oncotarget, 5(24), 12472-12508. RIS download Bibtex download
  • (2014) , 5(24). RIS download Bibtex download
  • Highley JR, Gebril OH, Simpson JE, Wharton SB, Kirby J, O'Brien JT, Barber R, Kalaria RN, Brayne C, Lewis CE , Shaw PJ et al (2014) . Journal of Aging Science, 2(1). RIS download Bibtex download
  • Chen Y-Y, Brown NJ, Jones R, Lewis CE, Mujamammi AH, Muthana M, Seed MP & Barker MD (2014) . Angiogenesis, 17(1), 207-219. RIS download Bibtex download
  • De Palma M & Lewis CE (2013) . CANCER CELL, 23(3), 277-286. RIS download Bibtex download
  • Muthana M, Rodrigues S, Chen Y-Y, Welford A, Hughes R, Tazzyman S, Essand M, Morrow F & Lewis CE (2013) . Cancer Res, 73(2), 490-495. RIS download Bibtex download
  • Muthana M, Richardson J, Rodrigues S & Lewis C (2013) . BIO-PROTOCOL, 3(13). RIS download Bibtex download
  • Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN & Miller G (2013) . Genesis, 51(1), 41-49. RIS download Bibtex download
  • De Palma M & Lewis CE (2011) CANCER Macrophages limit chemotherapy. NATURE, 472(7343), 303-304. RIS download Bibtex download
  • Abigail WF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Serio CD, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) . Cancer Research, 71(8_Supplement), 2849-2849. RIS download Bibtex download
  • Owen MR, Stamper IJ, Muthana M, Richardson GW, Dobson J, Lewis CE & Byrne HM (2011) . Cancer Res, 71(8), 2826-2837. RIS download Bibtex download
  • Lewis CE & Ferrara N (2011) . Cancer Cell, 19(4), 431-433. RIS download Bibtex download
  • Welford AF, Biziato D, Coffelt SB, Nucera S, Fisher M, Pucci F, Di Serio C, Naldini L, De Palma M, Tozer GM & Lewis CE (2011) . J Clin Invest, 121(5), 1969-1973. RIS download Bibtex download
  • Coffelt SB, Chen Y-Y, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M & Lewis CE (2011) . J Immunol, 186(7), 4183-4190. RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Fang H-Y, Coffelt SB, Morrow FJ, Murdoch C, Burton J, Cross N, Burke B , Mistry R et al (2011) . Cancer Res, 71(5), 1805-1815. RIS download Bibtex download
  • Tazzyman S, Barry ST, Ashton S, Wood P, Blakey D, Lewis CE & Murdoch C (2011) . Int J Cancer, 129(4), 847-858. RIS download Bibtex download
  • Krajewska E, Lewis C, Staton C, MacGowan A & MacNeil S (2011) . Journal of Tissue Engineering and Regenerative Medicine, 5(5), 363-374. RIS download Bibtex download
  • Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y & Lewis CE (2010) . Cancer Res, 70(13), 5270-5280. RIS download Bibtex download
  • Biswas SK & Lewis CE (2010) . J Leukoc Biol, 88(5), 877-884. RIS download Bibtex download
  • Coffelt SB, Lewis CE, Naldini L, Brown JM, Ferrara N & De Palma M (2010) . Am J Pathol, 176(4), 1564-1576. RIS download Bibtex download
  • Krajewska E, Lewis CE, Chen Y-Y, Welford A, Tazzyman S & Staton CA (2010) . Br J Cancer, 102(3), 594-601. RIS download Bibtex download
  • Tazzyman S, Lewis CE & Murdoch C (2009) . Int J Exp Pathol, 90(3), 222-231. RIS download Bibtex download
  • Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E , Greten FR et al (2009) . Blood, 114(4), 844-859. RIS download Bibtex download
  • Coffelt SB, Hughes R & Lewis CE (2009) . Biochim Biophys Acta, 1796(1), 11-18. RIS download Bibtex download
  • Ryan RM, Green J, Williams PJ, Tazzyman S, Hunt S, Harmey JH, Kehoe SC & Lewis CE (2009) . Gene Ther, 16(3), 329-339. RIS download Bibtex download
  • Hagemann T, Biswas SK, Lawrence T, Sica A & Lewis CE (2009) . BLOOD, 113(14), 3139-3146. RIS download Bibtex download
  • Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R , Kalaria RN et al (2009) . Stroke, 40(2), 369-375. RIS download Bibtex download
  • Elbarghati L, Murdoch C & Lewis CE (2008) . Immunobiology, 213(9-10), 899-908. RIS download Bibtex download
  • Murdoch C, Muthana M, Coffelt SB & Lewis CE (2008) . Nat Rev Cancer, 8(8), 618-631. RIS download Bibtex download
  • Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J & Lewis CE (2008) . Gene Ther, 15(12), 902-910. RIS download Bibtex download
  • Larsen M, Tazzyman S, Lund EL, Junker N, Lewis CE, Kristjansen PEG & Murdoch C (2008) . CANCER LETT, 265(2), 239-249. RIS download Bibtex download
  • Biswas SK, Sica A & Lewis CE (2008) Plasticity of macrophage function during tumor progression: Regulation by distinct molecular mechanisms. J IMMUNOL, 180(4), 2011-2017. RIS download Bibtex download
  • Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE & Hanahan D (2008) . Neoplasia, 10(4), 329-339. RIS download Bibtex download
  • Lewis C (2008) Research alert: Gene therapy - Microscopic magnets attached to human cells offer hope for cancer treatment. Biomedical Materials(JUNE), 10. RIS download Bibtex download
  • Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN , Brayne C et al (2007) . Neuropathol Appl Neurobiol, 33(6), 670-683. RIS download Bibtex download
  • De Palma M, Murdoch C, Venneri MA, Naldin L & Lewis CE (2007) . TRENDS IMMUNOL, 28(12), 519-524. RIS download Bibtex download
  • Staton CA, Lewis C & Bicknell R (2007) . Angiogenesis Assays: A Critical Appraisal of Current Techniques. RIS download Bibtex download
  • Lewis CE, De Palma M & Naldini L (2007) . Cancer Res, 67(18), 8429-8432. RIS download Bibtex download
  • Lewis CE & Hughes R (2007) . Breast Cancer Res, 9(3), 209. RIS download Bibtex download
  • Murdoch C, Tazzyman S, Webster S & Lewis CE (2007) . J Immunol, 178(11), 7405-7411. RIS download Bibtex download
  • Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C , Shaw PJ et al (2007) . Neuropathol Appl Neurobiol, 33(4), 410-419. RIS download Bibtex download
  • Staton CA, Stribbling SM, García-Echeverría C, Bury JP, Tazzyman S, Lewis CE & Brown NJ (2007) . J Thromb Haemost, 5(4), 846-854. RIS download Bibtex download
  • Webb SD, Owen MR, Byrne HM, Murdoch C & Lewis CE (2007) . B MATH BIOL, 69(5), 1747-1776. RIS download Bibtex download
  • Lin EY, Li J-F, Gnatovskiy L, Deng Y, Zhu L, Grzesik DA, Qian H, Xue X-N & Pollard JW (2006) . Cancer Research, 66(23), 11238-11246. RIS download Bibtex download
  • Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB , Shaw PJ et al (2006) . Stroke, 37(6), 1391-1398. RIS download Bibtex download
  • Lewis CE & Pollard JW (2006) . Cancer Res, 66(2), 605-612. RIS download Bibtex download
  • Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, Lewis CE & Shaw PJ (2006) . J Neuropathol Exp Neurol, 65(1), 26-36. RIS download Bibtex download
  • Ryan RM, Green J & Lewis CE (2006) . Bioessays, 28(1), 84-94. RIS download Bibtex download
  • MacRae EJ, Giannoudis A, Ryan R, Brown NJ, Hamdy FC, Maitland N & Lewis CE (2006) . Prostate, 66(5), 470-494. RIS download Bibtex download
  • Bingle L, Lewis CE, Corke KP, Reed MWR & Brown NJ (2006) . Br J Cancer, 94(1), 101-107. RIS download Bibtex download
  • Staton CA & Lewis CE (2005) . J Cell Mol Med, 9(2), 286-302. RIS download Bibtex download
  • Murdoch C, Muthana M & Lewis CE (2005) . J Immunol, 175(10), 6257-6263. RIS download Bibtex download
  • Murdoch C & Lewis CE (2005) . Int J Cancer, 117(5), 701-708. RIS download Bibtex download
  • Brockington A, Kirby J, Eggitt D, Schofield E, Morris C, Lewis CE, Ince PG & Shaw PJ (2005) . NEUROGENETICS, 6(2), 101-104. RIS download Bibtex download
  • Franks SJ, Byrne HM, Underwood JCE & Lewis CE (2005) . J Theor Biol, 232(4), 523-543. RIS download Bibtex download
  • Lewis C & Murdoch C (2005) . The American Journal of Pathology, 167(3), 627-635. RIS download Bibtex download
  • Staton CA, Stribbling SM, Tazzyman S, Hughes R, Brown NJ & Lewis CE (2004) . Int J Exp Pathol, 85(5), 233-248. RIS download Bibtex download
  • Stribbling SM, Bury JP, Corke KP, Lewis CE & Brown NJ (2004) . Microcirculation, 11(6), 552-553. RIS download Bibtex download
  • Staton CA, Brown NJ, Rodgers G, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) . Microcirculation, 11(6), 531-532. RIS download Bibtex download
  • Brockington A, Lewis C, Wharton S & Shaw PJ (2004) . Neuropathology and Applied Neurobiology, 30(5), 427-446. RIS download Bibtex download
  • Murdoch C, Giannoudis A & Lewis CE (2004) . Blood, 104(8), 2224-2234. RIS download Bibtex download
  • Owen MR, Byrne HM & Lewis CE (2004) . J THEOR BIOL, 226(4), 377-391. RIS download Bibtex download
  • Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCE & Lewis CE (2004) . Blood, 103(2), 601-606. RIS download Bibtex download
  • Peters CL, Morris CJ, Mapp PI, Blake DR, Lewis CE & Winrow VR (2004) . ARTHRITIS RHEUM, 50(1), 291-296. RIS download Bibtex download
  • Ameri K, Lewis CE, Raida M, Sowter H, Hai TW & Harris AL (2004) . BLOOD, 103(5), 1876-1882. RIS download Bibtex download
  • Staton CA, Brown NJ & Lewis CE (2003) . Expert Opin Biol Ther, 3(7), 1105-1120. RIS download Bibtex download
  • Daly ME, Makris A, Reed M & Lewis CE (2003) . J Natl Cancer Inst, 95(22), 1660-1673. RIS download Bibtex download
  • Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L & Lewis CE (2003) . Am J Pathol, 163(4), 1233-1243. RIS download Bibtex download
  • Franks SJ, Byrne HM, Mudhar HS, Underwood JCE & Lewis CE (2003) Mathematical modelling of comedo ductal carcinoma in situ of the breast. MATH MED BIOL, 20(3), 277-308. RIS download Bibtex download
  • Franks SJ, Byrne HM, King JR, Underwood JCE & Lewis CE (2003) . J MATH BIOL, 47(5), 424-452. RIS download Bibtex download
  • Breward CJW, Byrne HM & Lewis CE (2003) . B MATH BIOL, 65(4), 609-640. RIS download Bibtex download
  • Ameri K, Burke B, Lewis CE & Harris AL (2002) . Br J Cancer, 87(10), 1173-1181. RIS download Bibtex download
  • Baluch CJ, Burke B, Corke K, Wells M, Smith J, Tidy J, Coleman R & Lewis CE (2002) Expression of hypoxia inducible factor-1 in metastatic tumour's in ovarian cancer: link with p53 expression and relevance to hypoxia-targeted gene therapies for disseminated disease. J PATHOL, 198, 5A-5A. RIS download Bibtex download
  • Burke B, Sumner S, Maitland N & Lewis CE (2002) Macrophages in gene therapy: cellular delivery vehicles and in vivo targets. J LEUKOCYTE BIOL, 72(3), 417-428. RIS download Bibtex download
  • Breward CJW, Byrne HM & Lewis CE (2002) . J MATH BIOL, 45(2), 125-152. RIS download Bibtex download
  • Brown NJ, Staton CA, Rodgers GR, Corke KP, Underwood JCE & Lewis CE (2002) . Br J Cancer, 86(11), 1813-1816. RIS download Bibtex download
  • Bingle L, Brown NJ & Lewis CE (2002) . J Pathol, 196(3), 254-265. RIS download Bibtex download
  • Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M & Lewis CE (2002) . J Pathol, 196(2), 204-212. RIS download Bibtex download
  • Kelly CE, Leek RD, Byrne HM, Cox SM, Harris AL & Lewis CE (2002) . Journal of Theoretical Medicine, 4(1), 21-39. RIS download Bibtex download
  • Breward CJW, Byrne HM & Lewis CE (2001) Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour. EUR J APPL MATH, 12, 529-556. RIS download Bibtex download
  • Crowther M, Brown NJ, Bishop ET & Lewis CE (2001) Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors.. J Leukoc Biol, 70(4), 478-490. RIS download Bibtex download
  • Burton JL, Wells JM, Corke KP, Maitland NJ, Harndy FC & Lewis CE (2001) Hypoxic macrophages accumulate in avascular, hypoxic areas of prostate cancer and benign prostatic hyperplasia.. J PATHOL, 195, 33A-33A. RIS download Bibtex download
  • Hehlgans T, Seitz C, Lewis C & Männel DN (2001) . Journal of Interferon & Cytokine Research, 21(9), 757-762. RIS download Bibtex download
  • Donovan D, Brown NJ, Bishop ET & Lewis CE (2001) . Angiogenesis, 4(2), 113-121. RIS download Bibtex download
  • Gammack D, Byrne HM & Lewis CE (2001) Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia. B MATH BIOL, 63(1), 135-166. RIS download Bibtex download
  • Bootle-Wilbraham CA, Tazzyman S, Thompson WD, Stirk CM & Lewis CE (2001) . Angiogenesis, 4(4), 269-275. RIS download Bibtex download
  • Hollander AP, Corke KP, Freemont AJ & Lewis CE (2001) Expression of hypoxia-inducible factor la by macrophages in the rheumatoid synovium - Implications for targeting of therapeutic genes to the inflamed joint. ARTHRITIS RHEUM, 44(7), 1540-1544. RIS download Bibtex download
  • Burton JL, Wells JM, Corke KP, Maitland N, Hamdy FC & Lewis CE (2000) Macrophages accumulate in avascular, hypoxic areas of prostate tumours: implications for targeted therapeutic gene delivery to such sites.. J PATHOL, 192, 8A-8A. RIS download Bibtex download
  • Ferreux E, Lewis CE, Perrett CW & Wells M (2000) The role of p53 gene status in modulating the effects of hypoxia on human epithelial ovarian cancer cells. J PATHOL, 192, 10A-10A. RIS download Bibtex download
  • Landers RJ, Underwood JCE, Evans CA, Lawry J, Leek RD, Harris AL & Lewis CE (2000) Macrophage expression of urokinase receptors correlates with macrophage infiltration and angiogenesis in invasive carcinoma of the breast: Regulation by hypoxia. J PATHOL, 192, 20A-20A. RIS download Bibtex download
  • Bootle-Wilbraham CA, Tazzyman S, Marshall JM & Lewis CE (2000) Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro.. Cancer Res, 60(17), 4719-4724. RIS download Bibtex download
  • Ameri K, Lewis CE, Burke B & Harris AL (2000) Characterisation of hypoxia responsive element activity under anoxia in breast cancer cells: Role of HIF-1 and ATF-4. BRIT J CANCER, 83, 11-11. RIS download Bibtex download
  • Leek RD, Hunt NC, Landers RJ, Lewis CE, Royds JA & Harris AL (2000) Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J PATHOL, 190(4), 430-436. RIS download Bibtex download
  • Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S & Naylor S (2000) . Gene Therapy, 7(3), 255-262. RIS download Bibtex download
  • Lewis JS, Landers RJ, Underwood JC, Harris AL & Lewis CE (2000) Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas.. J Pathol, 192(2), 150-158. RIS download Bibtex download
  • Lewis JS, Lee JA, Underwood JC, Harris AL & Lewis CE (1999) . J Leukoc Biol, 66(6), 889-900. RIS download Bibtex download
  • Leek RD, Landers RJ, Harris AL & Lewis CE (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. BRIT J CANCER, 79(5-6), 991-995. RIS download Bibtex download
  • Kingsman SM, Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Lewis C, Harris A & Naylor S (1999) . Nature Biotechnology, 17(S4), 38-38. RIS download Bibtex download
  • Ferreux E, Wells M, Perrett CP & Lewis CE (1999) Regulation of angiogenesis in ovarian cancer: role of p53, vascular endothelial growth factor and hypoxia.. J PATHOL, 189, 16A-16A. RIS download Bibtex download
  • Lewis JS, Landers RJ, Underwood JCE, Harris AL & Lewis CE (1999) Expression of vascular endothelial growth factor by macrophages is upregulated in poorly vascularised areas of breast carcinomas. J PATHOL, 189, 13A-13A. RIS download Bibtex download
  • Zhang L, Scott PAE, Turley H, Leek R, Lewis CE, Gatter KC, Harris AL, Mackenzie IZ, Rees MCP & Bicknell R (1998) Validation of anti-vascular endothelial growth factor (anti-VEGF) antibodies for immunohistochemical localization of VEGF in tissue sections: Expression of VEGF in the human endometrium. J PATHOL, 185(4), 402-408. RIS download Bibtex download
  • Landers RJ, Leek RD, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor and its receptors with thymidine phosphorylase expression and metastasis in human breast cancer. J PATHOL, 182, A16-A16. RIS download Bibtex download
  • Royds JA, Dower SK, Qwarnstrom EE & Lewis CE (1998) . Mol Pathol, 51(2), 55-61. RIS download Bibtex download
  • Leek RD, Landers R, Fox SB, Ng F, Harris AL & Lewis CE (1998) Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. BRIT J CANCER, 77(12), 2246-2251. RIS download Bibtex download
  • CAMPBELL AP, SMITHSON J, LEWIS C, KETTLEWELL MGW, MORTENSEN N, JEWELL DP & McGEE JO (1996) . The Journal of Pathology, 180(4), 407-414. RIS download Bibtex download
  • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J & Harris AL (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Research, 56(20), 4625-4629. RIS download Bibtex download
  • O'Sullivan C & Lewis CE (1994) . The Journal of Pathology, 172(3), 229-235. RIS download Bibtex download
  • Leek RD, Harris AL & Lewis CE (1994) . Journal of Leukocyte Biology, 56(4), 423-435. RIS download Bibtex download
  • Bromley L, McCarthy SP, Stickland JE, Lewis CE & McGee JO (1994) . Journal of Immunological Methods, 167(1-2), 47-54. RIS download Bibtex download
  • Pusztai L, Clover LM, Cooper K, Starkey PM, Lewis CE & McGee JO (1994) . Br J Cancer, 70(2), 289-292. RIS download Bibtex download
  • Pusztai L, Lewis CE, Lorenzen J & McGee JO (1993) . The Journal of Pathology, 169(2), 191-201. RIS download Bibtex download
  • O'Sullivan C, Lewis CE, McGee JO & Harris AL (1993) . The Lancet, 342(8864), 148-149. RIS download Bibtex download
  • Pusztai L, Lewis CE & McGee JO (1993) . Br J Cancer, 67(2), 290-296. RIS download Bibtex download
  • Pusztai L, Lewis CE & McGee JO (1993) . Cytokine, 5(2), 169-172. RIS download Bibtex download
  • BAIGRIE R (1992) . Cytokine, 4(1), 63-65. RIS download Bibtex download
  • Lewis CE, McCracken D, Ling R, Richards PS, McCarthy SR & McGee JO (1991) . Immunological Reviews, 119(1), 23-39. RIS download Bibtex download
  • Lewis CE (1991) . Cytokine, 3(3), 184-188. RIS download Bibtex download
  • Lewis CE, Ramshaw AL, Lorenzen J & McGee JO (1991) . Cellular Immunology, 132(1), 158-167. RIS download Bibtex download
  • Lorenzen J, Lewis CE, McCracken D, Horak E, Greenall M & McGee JO (1991) . Br J Cancer, 64(3), 457-462. RIS download Bibtex download
  • Lewis CE, McCarthy SP, Richards PS, Lorenzen J, Horak E & O'D McGee J (1990) . Journal of Immunological Methods, 127(1), 51-59. RIS download Bibtex download
  • McCarthy SP, Lewis CE & McGee JO (1990) . Journal of Hepatology, 10(1), 90-98. RIS download Bibtex download
  • Lewis CE, McCarthy SP, Lorenzen J & McGee O'D. J (1990) Differential effects of LPS, IFN-γ and TNFα on the secretion of lysozyme by individual human mononuclear phagocytes: Relationship to cell maturity. Immunology, 69(3), 402-408. RIS download Bibtex download
  • Lewis CE, Mccarthy SP, Lorenzen J & Mcgee JOD (1989) . European Journal of Immunology, 19(11), 2037-2043. RIS download Bibtex download
  • Lewis CE, Richards PSM & Morris JF (1989) . Journal of Molecular Endocrinology, 2(1), 55-63. RIS download Bibtex download
  • Lewis CE, Clark A, Ashcroft SJH, Cooper GJS & Morris JF (1988) . Molecular and Cellular Endocrinology, 57(1-2), 41-49. RIS download Bibtex download
  • Cooper GJS, Willis AC, Reid KBM, Clark A, Baker CA, Turner RC, Lewis CE, Morris JF, Howland K & Rothbard JB (1987) . The Lancet, 330(8565), 966-966. RIS download Bibtex download
  • Clark A, Lewis CE, Willis AC, Cooper GJS, Morris JF, Reid KBM & Turner RC (1987) . The Lancet, 330(8553), 231-234. RIS download Bibtex download
  • Lewis CE, Fink G, Dow RC & Morris JF (1986) . Neuroendocrinology, 43(5), 584-589. RIS download Bibtex download
  • Lewis CE, Megson A, Morris JF & Charlton HM (1986) . Journal of Endocrinology, 111(3), 483-NP. RIS download Bibtex download
  • Lewis CE, Morris JF, Fink G & Johnson M (1986) . Journal of Endocrinology, 109(1), 35-NP. RIS download Bibtex download
  • Lewis CE, Morris JF & Fink G (1985) . Journal of Endocrinology, 106(2), 211-NP. RIS download Bibtex download

Chapters

  • Staton CA & Lewis CE (2006) Alphastatin: a pluripotent inhibitor of activated endothelial cells In Siemann DW (Ed.), Vascular-targeted therapies in oncology (pp. 205-220). Wiley-Blackwell RIS download Bibtex download
  • Burke B, Lewis JS & Lewis CE (2000) , Cytokine Cell Biology (pp. 147-171). Oxford University PressOxford RIS download Bibtex download

Conference proceedings papers

  • Al-janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) . Cancer Research, Vol. 81(13_Supplement) (pp 2797-2797) RIS download Bibtex download
  • Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) . Cancer Research, Vol. 81(13_Supplement) (pp 2720-2720) RIS download Bibtex download
  • Al-Janabi H, Pu X, Muthana M, Wang N, Crespo M, Gurel B, De Bono J, Brown JE & Lewis CE (2021) Changes in the phenotype of macrophages and CD8+T Cells in the perivascular niche of prostate tumours following androgen deprivation.. CANCER RESEARCH, Vol. 81(13) RIS download Bibtex download
  • Moamin MR, Allen RJ, Stavrou N, Nagy M, Juncker-Jensen A & Lewis CE (2021) Perivascular accumulation of immunosuppressive cells in the stroma of human triple negative breast carcinomas: implications for immunotherapy.. CANCER RESEARCH, Vol. 81(13) RIS download Bibtex download
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) . Cancer Research, Vol. 79(13_Supplement) RIS download Bibtex download
  • Pu X, AL-Janabi H, Wang N, Muthana M, Brown J & Lewis C (2019) . Tumor Biology RIS download Bibtex download
  • Tazzyman S, Muthana M, Harrison J, Lewis C, Conner J & Chantry A (2015) . Journal of Clinical Oncology, Vol. 33(15_suppl) (pp e14035-e14035) RIS download Bibtex download
  • Hughes R, Murdoch C, Fang H-Y & Lewis C (2007) Microenvironmental signals regulating the tumour-promoting functions of macrophages: role of hypoxia and necrotic debris. JOURNAL OF LEUKOCYTE BIOLOGY (pp 56-56) RIS download Bibtex download
  • Ince PG, Fernando MS, Matthews F, Brayne C, Wharton SB, O'Brien JT, Lewis C, Kalaria RN, Shaw PJ & Simpson J (2006) Molecular markers of tissue hypoxia and glial pathology associated with incidental white matter lesions in the ageing brain. BRAIN PATHOLOGY, Vol. 16 (pp S92-S92) RIS download Bibtex download
  • Muthana M, Giannoudis A, Scott SD, Burke B, Mistry R, Hamdy F, Brown N, Maitland N & Lewis CE (2006) Engineering macrophages to synthesize recombinant adenoviruses in hypoxic areas of human prostate tumors. CANCER RESEARCH, Vol. 66(8) RIS download Bibtex download
  • Lewis CE, Leek R, Harris A & McGee JO (1995) . Journal of Leukocyte Biology, Vol. 57(5) (pp 747-751) RIS download Bibtex download
  • PUSZTAI L, LEWIS CE, LORENZEN J & MCGEE JO (1991) REGULATION OF BREAST-CANCER CELL-GROWTH BY TGF-BETA, IFN-GAMMA, IL6 AND IL4. JOURNAL OF PATHOLOGY, Vol. 163(2) (pp A170-A170) RIS download Bibtex download

Preprints

  • Al-janabi H, Moyes K, Allen R, Fisher M, Crespo M, Gurel B, Rescigno P, De Bono J, Nunns H, Bailey C , Juncker-Jensen A et al (2024) , Cold Spring Harbor Laboratory. RIS download Bibtex download
  • Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I , Endermann T et al (2018) , Cold Spring Harbor Laboratory. RIS download Bibtex download
Research group

Group Members

  • Professor Claire Lewis
  • Dr Mohammed Ridha (Postdoc)
  • Dr Haider Al-Janabi (Postdoc)
  • Katy Moyes (Postgraduate RA)
  • Richard Allen (PhD student)
Teaching interests
  • Acute and chronic inflammation
  • Angiogenesis in human diseases
  • Cancer
Professional activities and memberships

Journals

  • Member of the Editorial Board, Frontiers in Immunology.
  • Member of the Editorial Board, Cancer Research.
  • Member of the Editorial Board, Cancers.
  • Member of the Editorial Board, Journal of Clinical Investigation Insight.
  • Member of the Editorial Board, OncoImmunology.
  • Member of the Editorial Board, International Journal of Cancer.
  • Associate Editor, International Journal of Experimental Pathology.

Grant Awarding Bodies

  • Member, MRC/NIHR UK-US Cancer Skills Development Panel (2023 -  present).
  • Member, MRC Molecular & Cellular Medicines Board (2018-2022).
  • Member, PCUK Research Advisory Committee (2019-2022).
  • Member, Quinquennial Review Panel, MRC Human Immunology Unit, Oxford, Nov. 2016.
  • Member, Quinquennial Review Panel, Breast Cancer Now Manchester Research Unit, Feb. 2016.
  • Member, Senior Investigator Awards Committee, The Wellcome Trust, (2013).
  • Member of 3 Scientific Advisory Boards: ‘Cancer Immunotherapy’, Tumour Inflammation’ and ‘Metastasis’ for the Cancer Section of EU Framework 7 (2007- present).
  • Member, International Science Evaluation Panel (for biology, medicine and health), The Research Council, Norway (2011).
  • Member, AACR Basic Cancer Research Grants Scientific Review Committee (2010).
  • Chair, BBSRC Review Panel in Interdisciplinary Research (2005).
  • MRC College of Experts - Molecular and Cellular Medicine Board, (2004-current).
  • EPSRC Peer Review College (2006-2009).
  • Member, Scientific Advisory Board, Breast Cancer Campaign (1999-2002).