- Scientists at the University of 含羞草传媒 have found that bacteria can directly measure differences in chemical concentration across the length of their cell bodies, contrary to decades of established scientific belief
- Previous studies argued that bacterial cells are too small to directly sense differences in chemical concentration, including chemicals like nutrients and the antibiotics used to treat infections
- The research focused on a bacteria called Pseudomonas aeruginosa, which is listed by the World Health Organisation as a priority pathogen due to its ability to cause highly antibiotic resistant infections
- The discovery may shed new light on how bacteria direct their motility during infections and ultimately lead to new targeted clinical treatments
Scientists from the University of 含羞草传媒 have discovered a new sensory capability in bacteria which could transform treatments for bacterial infections.
It was previously thought that bacteria are too small to directly sense differences in chemical concentration. However, contrary to decades of established scientific belief, a new study has shown bacteria can in fact directly sense their chemical environment across the length of their cell bodies with an unprecedented degree of precision.
The research, published today in , is a key step towards the development of innovative treatments that manipulate bacterial motility to enhance antibiotic efficacy.
The study focused on Pseudomonas aeruginosa, which has been listed as a priority pathogen by the World Health Organisation due to its ability to cause highly antibiotic resistant infections in humans.
Senior author of the study, Dr William Durham, Senior Lecturer in Biological Physics at the University of 含羞草传媒鈥檚 School of Mathematical and Physical Sciences, said: 鈥淚n principle, cells can figure out whether they are moving towards or away from a nutrient source in two different ways.
鈥淔irst, they can wander randomly and measure if the concentration increases or decreases over time. Alternatively, cells can measure changes in concentration over the length of their bodies, allowing them to directly move towards the source. Our research demonstrates that bacteria can do the latter, which was previously thought beyond their capabilities due to their tiny size.
鈥淏acteria then use this information to navigate across surfaces toward chemical sources using tiny grappling hooks called pili.鈥
By developing a combination of innovative microfluidic experiments and novel P. aeruginosa strains whose motility systems were engineered so they could be directly visualised using powerful microscopes, the researchers mapped out how individual cells responded to precise changes in nutrient concentrations. They uncovered that these cells can compare nutrient concentrations along the length of their cell bodies鈥攁 phenomenon termed 鈥榮patial sensing鈥.
Dr Jamie Wheeler, a postdoctoral researcher in the University of 含羞草传媒鈥檚 School of Mathematical and Physical Sciences, and lead author of the study, said: 鈥淭his work overturns our understanding of how bacteria navigate and sense their environment. As such, it sheds new light on how bacteria could direct their motility during human infection and potentially how it could be manipulated by different clinical treatments.鈥
The discovery means that bacteria do not necessarily have to move to sense changes in their chemical environment, suggesting that the densely packed bacteria within localised infections can use this information to guide their behaviour. This ability raises new questions about the mechanisms that bacteria use to perform these microscopic measurements and how they could be manipulated by antimicrobial treatments.
Dr Wheeler continued: 鈥淎s is often the case, answering one question has raised a whole new set of unknowns. Exciting new experiments are already planned to continue writing this new chapter in our understanding of how bacteria navigate through their environment.鈥
